3-甲基-4-硝基-1H-吡唑-5-羧酸合成路线 （共 17 条）
反应条件
1: thionyl chloride / 4 h / Reflux
2: diethyl ether; water / 8 h / 0 - 20 °C
View Scheme
参考文献
Zhang, Da Qiang; Xu, Gao Fei; Fan, Zhi Jin; Wang, Dao Quan; Yang, Xin Ling; Yuan, De Kai
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 669 - 672
反应条件
1: thionyl chloride / 4 h / Reflux
2: diethyl ether; water / 8 h / 0 - 20 °C
3: 0.5 Pd/C; hydrogen / methanol / 24 h / 20 °C / 6080.41 Torr
View Scheme
参考文献
Zhang, Da Qiang; Xu, Gao Fei; Fan, Zhi Jin; Wang, Dao Quan; Yang, Xin Ling; Yuan, De Kai
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 669 - 672
反应条件
hydrogenchloride; water; tin(ll) chloride
参考文献
Robins et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 833,835,836
反应条件
1: 1.) aq. KOH, KMnO4, 2.) AgNO3 / 1.) reflux, 5 h, 2.) water, reflux, 15 min
2: 44 percent / conc. H2SO4 / 24 h / Heating
View Scheme
参考文献
Baraldi; Leoni; Cacciari; Manfredini; Simoni; Bergomi; Menta; Spinelli
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4329 - 4337
反应条件
2: water; NH3
3: ethanol; palladium/charcoal / Hydrogenation
5: pyridine; P2S5
View Scheme
参考文献
Robins et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 833,835,836
反应条件
2: water; NH3
3: ethanol; palladium/charcoal / Hydrogenation
5: N,N-dimethyl-aniline; POCl3
View Scheme
参考文献
Robins et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 833,835,836
反应条件
potassium hydroxide; potassium permanganate; silver nitrate
1.) reflux, 5 h, 2.) water, reflux, 15 min; Yield given. Multistep reaction;
参考文献
Baraldi; Leoni; Cacciari; Manfredini; Simoni; Bergomi; Menta; Spinelli
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4329 - 4337
