5-氨基-1-甲基-吡唑-4-甲腈合成路线 （共 27 条）
反应条件
hydrogenchloride; sodium nitrite; sulfur dioxide 1) < 10 deg C, 30 min, 2) CCl4, room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Susumu; Morimoto, Katsushi; Sato, Toshiaki
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1545 - 1547
反应条件
water; sodium hydroxide Reflux;
参考文献
Dounay, Amy B.; Anderson, Marie; Bechle, Bruce M.; Evrard, Edelweiss; Gan, Xinmin; Kim, Ji-Young; McAllister, Laura A.; Pandit, Jayvardhan; Rong, Suobao; Salafia, Michelle A.; Tuttle, Jamison B.; Zawadzke, Laura E.; Verhoest, Patrick R.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 1961 - 1966
反应条件
acetonitrile T=100°C; 15 h; Sealed tube;
参考文献
Roecker, Anthony J.; Mercer, Swati P.; Harrell, C. Meacham; Garson, Susan L.; Fox, Steven V.; Gotter, Anthony L.; Prueksaritanont, Thomayant; Cabalu, Tamara D.; Cui, Donghui; Lemaire, Wei; Winrow, Christopher J.; Renger, John J.; Coleman, Paul J.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 9 p. 2079 - 2085
反应条件
hydrogenchloride; sodium nitrite; sulfur dioxide 1) < 10 deg C, 30 min, 2) CCl4, room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Susumu; Morimoto, Katsushi; Sato, Toshiaki
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1545 - 1547
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1956 , vol. 21, p. 1240,1242
反应条件
Erhitzen des Reaktionsprodukts mit wss.HCl;
参考文献
Bamoharram, Fatemeh Farrash
Molecules, 2010 , vol. 15, # 4 p. 2509 - 2519
反应条件
pyridine 10 h; Heating;
参考文献
Bhuiyan; Rahman, Khandker M.M.; Hossain; Rahim
Pakistan Journal of Scientific and Industrial Research, 2005 , vol. 48, # 5 p. 318 - 321
反应条件
phosphoric acid T=170 - 180°C; 20 h;
参考文献
Lynch; Khan; Teo; Pedrotti
Canadian Journal of Chemistry, 1988 , vol. 66, # 3 p. 420-428
反应条件
1: sodium hydroxide; water / |Reflux 2: sodium nitrite; tetrafluoroboric acid / water View Scheme
参考文献
Dounay, Amy B.; Anderson, Marie; Bechle, Bruce M.; Evrard, Edelweiss; Gan, Xinmin; Kim, Ji-Young; McAllister, Laura A.; Pandit, Jayvardhan; Rong, Suobao; Salafia, Michelle A.; Tuttle, Jamison B.; Zawadzke, Laura E.; Verhoest, Patrick R.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 1961 - 1966
反应条件
1: With sulfuric acid T=20°C; 1 h; 2: With ammonia; water pH=8; Cooling with ice; Product distribution / selectivity;
参考文献
GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG
Patent: WO2009/97446 A1, 2009 ;
Location in patent: Page/Page column 64 ;
WO 2009/097446 A1
