4-氯-1-苯基-1H-吡唑并[3,4-d]嘧啶合成路线 （共 63 条）
参考文献
Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101
参考文献
Jain, Kishor S.; Khedkar, Vijay M.; Arya, Nikhilesh; Rane, Prasad V.; Chaskar, Pratip K.; Coutinho, Evans C.
European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 166 - 175
反应条件
hydrazine hydrate in ethanol
T=45°C; 24 h;
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125
反应条件
sodium hydride; [mmim][I] in N,N-dimethyl-formamide
0.333333 h; Ambient temperature;
参考文献
Miyashita; Matsuda; Suzuki; Iwamoto; Higashino
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 10 p. 2017 - 2022
反应条件
1: 33 percent / NaH (50percent in oil) / dimethylformamide / 0.5 h / 40 - 50 °C
2: 58 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
3: 84 percent / 50percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
4: 75 percent / K3Fe(CN)6, 50percent NaOH / H2O; benzene / 1 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
1: 60 percent / NaH (50percent in oil) / dimethylformamide / 0.17 h / 0 °C
2: 20 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
potassium cyanide in N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Ohta, Kiyono; Iwamoto, Ken-Ichi; Higashino, Takeo
Heterocycles, 1998 , vol. 47, # 1 p. 407 - 414
反应条件
potassium cyanide; p-toluenesulfinic acid sodium salt in N,N-dimethyl-formamide
1 h; with/without sodium p-toluenesulfinate; Product distribution;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Ohta, Kiyono; Iwamoto, Ken-Ichi; Higashino, Takeo
Heterocycles, 1998 , vol. 47, # 1 p. 407 - 414
反应条件
1: 58 percent / NaH (50percent in oil) / dimethylformamide / 0.5 h / Ambient temperature
2: 57 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
sodium hydride; [mmim][I] in 1,4-dioxane
0.25 h; Heating;
参考文献
Miyashita; Matsuda; Suzuki; Iwamoto; Higashino
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 10 p. 2017 - 2022
