4-氯-1-苯基-1H-吡唑并[3,4-d]嘧啶合成路线 （共 63 条）
反应条件
potassium cyanide in N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Ohta, Kiyono; Iwamoto, Ken-Ichi; Higashino, Takeo
Heterocycles, 1998 , vol. 47, # 1 p. 407 - 414
反应条件
1: 57 percent / NaH (50percent in oil) / dimethylformamide / 0.5 h / Ambient temperature
2: 28 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
1: 60 percent / NaH (50percent in oil) / dimethylformamide / 0.5 h / Ambient temperature
2: 56 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
3: 82 percent / 50percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
4: 83 percent / K3Fe(CN)6, 50percent NaOH / H2O; benzene / 1 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
1: 58 percent / NaH (50percent in oil) / dimethylformamide / 0.5 h / Ambient temperature
2: 57 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
3: 86 percent / 50percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
4: 81 percent / K3Fe(CN)6, 50percent NaOH / H2O; benzene / 1 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
1: 57 percent / NaH (50percent in oil) / dimethylformamide / 0.5 h / Ambient temperature
2: 28 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
3: 82 percent / 50percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
4: 72 percent / K3Fe(CN)6, 50percent NaOH / H2O; benzene / 1 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
1: 60 percent / NaH (50percent in oil) / dimethylformamide / 0.17 h / 0 °C
2: 17 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
3: 83 percent / 50percent NaOH / dimethylsulfoxide / 3 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
1: 60 percent / NaH (50percent in oil) / dimethylformamide / 0.17 h / 0 °C
2: 17 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
1: 44 percent / NaH (50percent in oil) / dimethylformamide / 0.5 h / Ambient temperature
2: 62 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
3: 86 percent / 50percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
4: 85 percent / K3Fe(CN)6, 50percent NaOH / H2O; benzene / 1 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
in tetrahydrofuran
3 h; Heating;
参考文献
Miyashita, Akira; Sasaki, Takami; Oishi, Etsuo; Higashino, Takeo
Heterocycles, 1994 , vol. 37, # 2 p. 823 - 832
反应条件
1: 4-chloro-1-phenyl-1H-pyrazololt;3,4-dgt;pyrimidine With lithium n-butanetelluroate in tetrahydrofuran
T=20°C; 0.166667 h;
2: With n-butyllithium in tetrahydrofuran
T=-78°C; 0.166667 h;
3: acetone in tetrahydrofuran
T=-78 - 20°C;
参考文献
Sugimoto, Osamu; Sudo, Muneyoshi; Tanji, Ken-Ichi
Tetrahedron, 2001 , vol. 57, # 11 p. 2133 - 2138
