1-[2-(2-吡啶基)乙基]哌嗪合成路线 （共 9 条）
反应条件
1: With hydrogenchloride in water T=60 - 70°C; 2: With sodium hydroxide in water T=20 - 30°C; pH=12 - 12.5;
参考文献
US2010/331341 A1, ;
Page/Page column 14 ;
反应条件
triphenylphosphine; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate in tetrahydrofuran Alkylation; 20 h; Heating;
参考文献
European Journal of Inorganic Chemistry, , # 7 p. 1121 - 1132
反应条件
in water 1 h; Heatingexcess piperazine;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
反应条件
in chloroform
Ambient temperature;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
反应条件
in chloroform
Ambient temperature;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
反应条件
in acetonitrile
Ambient temperature;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
反应条件
in acetonitrile
Ambient temperature;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
反应条件
1.) half molar equiv. piperazine; 2.) AcOEt;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
反应条件
1.) CHCl3, r.t.; 2.) AcOEt;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
