4-(5-甲酰基-2-呋喃基)苯甲酸甲酯合成路线 （共 7 条）
反应条件
potassium fluoride; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane; hexane T=65 - 70°C; 4 h;
参考文献
CELL THERAPEUTICS EUROPE S.R.L.
Patent: WO2006/66846 A1, 2006 ;
Location in patent: Page/Page column 11; 12 ;
WO 2006/066846 A1
反应条件
potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0) in hexane; dichloromethane
参考文献
Cell Therapeutics, Inc.
Patent: US2004/2526 A1, 2004 ;
反应条件
triethylamine; palladium on activated charcoal in ethanol T=60°C; Suzuki cross-coupling reaction; 18 h;
参考文献
McClure; Roschangar; Hodson; Millar; Osterhout
Synthesis, 2001 , # 11 p. 1681 - 1685
反应条件
1: 5-iodofuran-2-carboxaldehyde With i -Pr2Zn; Li(acac) in 1-methyl-pyrrolidin-2-one T=20°C; 12 h; 2: 4-iodo-benzoic acid methyl ester With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=20°C; Negishi cross-coupling reaction; 24 h;
参考文献
Gong, Liu-Zhu; Knochel, Paul
Synlett, 2005 , # 2 art. no. G41404ST, p. 267 - 270
反应条件
sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water Suzuki coupling; 5 h; Heating;
参考文献
Mitsch, Andreas; Wissner, Pia; Silber, Katrin; Haebel, Peter; Sattler, Isabel; Klebe, Gerhard; Schlitzer, Martin
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4585 - 4600
反应条件
1.1: n-BuLi / dimethylformamide; hexane / 2 h / -20 °C 1.2: B(O-iPr)3 / dimethylformamide; hexane / -20 - 20 °C 1.3: AcOH; H2O / dimethylformamide; hexane / 20 °C 2.1: 78 percent / Et3N / 10 percent Pd/C / ethanol / 18 h / 60 °C View Scheme
参考文献
Synthesis, , # 11 p. 1681 - 1685
反应条件
hydrogenchloride; lithium hydroxide in methanol; water
参考文献
Cell Therapeutics, Inc.
Patent: US2004/2526 A1, 2004 ;
