3-硝基-5-三氟甲基-2-氨基吡啶合成路线 (共 5 条)
反应条件
sulfuric acid; nitric acid T=0 - 20°C; Inert atmosphere;
参考文献
Sapegin, Alexander V.; Kalinin, Stanislav A.; Smirnov, Alexey V.; Dorogov, Mikhail V.; Krasavin, Mikhail
Tetrahedron, 2014 , vol. 70, # 5 p. 1077 - 1083
参考文献
State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University and The University of Oregon, Eugene Oregon; The Regents of the University of California; ACEA Pharmaceuticals, Inc.
Patent: US5620978 A1, 1997 ;
US 5620978 A
反应条件
sulfuric acid; sodium nitrite in water T=0 - 20°C; Inert atmosphere;
参考文献
Sapegin, Alexander V.; Kalinin, Stanislav A.; Smirnov, Alexey V.; Dorogov, Mikhail V.; Krasavin, Mikhail
Tetrahedron, 2014 , vol. 70, # 5 p. 1077 - 1083
反应条件
1: sulfuric acid; sodium nitrite / water / 0 - 20 °C / |Inert atmosphere 2: trichlorophosphate / N,N-dimethyl-formamide / 12 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Sapegin, Alexander V.; Kalinin, Stanislav A.; Smirnov, Alexey V.; Dorogov, Mikhail V.; Krasavin, Mikhail
Tetrahedron, 2014 , vol. 70, # 5 p. 1077 - 1083
反应条件
1: 100 percent / H2 / Raney Ni / methanol / 2 h / 1551.4 - 2068.6 Torr 2: 94 percent / 2 h / 160 °C View Scheme
参考文献
Cugola, Alfredo; Donati, Daniele; Guarneri; Micheli, Fabrizio; Missio, Andrea; Pecunioso, Angelo; Reggiani, Angelo; Tarzia; Zanirato
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 22 p. 2749 - 2754