2-[(二甲基氨基)甲基]苯甲腈合成路线 （共 9 条）
反应条件
sulfuric acid 0.5 h; Heating;
参考文献
Brzezinski, Bogumil
Polish Journal of Chemistry, 1983 , vol. 57, # 1-3 p. 249 - 252
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78°C; 2 h; 2: With methanol in tetrahydrofuran; hexane T=20°C;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1612204 A1, 2006 ;
Location in patent: Page/Page column 42-43 ;
反应条件
in diethyl ether; water
T=20°C;
参考文献
Tayama, Eiji; Kimura, Hiroshi
Angewandte Chemie - International Edition, 2007 , vol. 46, # 46 p. 8869 - 8871
反应条件
1: 98 percent / methanol / 3 h / Heating
2: sodium borohydride / H2O / 3 h
3: 61 percent / methanol / 3 h / Heating
4: pyrrolidine / methanol / 25 °C / or triethylamine, N-methylpiperidine, morpholine, N-ethylmorpholine, N-methylmorpholine
View Scheme
参考文献
Nguyen, Minh Tho; Clarke, Leo F.; Hegarty, Anthony F.
Journal of Organic Chemistry, 1990 , vol. 55, # 25 p. 6177 - 6183
反应条件
1: 61 percent / methanol / 3 h / Heating
2: pyrrolidine / methanol / 25 °C / or triethylamine, N-methylpiperidine, morpholine, N-ethylmorpholine, N-methylmorpholine
View Scheme
参考文献
Nguyen, Minh Tho; Clarke, Leo F.; Hegarty, Anthony F.
Journal of Organic Chemistry, 1990 , vol. 55, # 25 p. 6177 - 6183
反应条件
1: sodium borohydride / H2O / 3 h
2: 61 percent / methanol / 3 h / Heating
3: pyrrolidine / methanol / 25 °C / or triethylamine, N-methylpiperidine, morpholine, N-ethylmorpholine, N-methylmorpholine
View Scheme
参考文献
Nguyen, Minh Tho; Clarke, Leo F.; Hegarty, Anthony F.
Journal of Organic Chemistry, 1990 , vol. 55, # 25 p. 6177 - 6183
反应条件
pyrrolidine in methanol
T=25°C;
参考文献
Nguyen, Minh Tho; Clarke, Leo F.; Hegarty, Anthony F.
Journal of Organic Chemistry, 1990 , vol. 55, # 25 p. 6177 - 6183
反应条件
O,O,O',O'-tetramethyl O,O'-thiodi-p-phenylene phosphorothioate
1.) CH2Cl2, 1 h, 2.) RT, 3 d; Multistep reaction;
参考文献
Affolter, Samuel; Pregosin, Paul S.
Journal of Organometallic Chemistry, 1990 , vol. 398, # 1/2 p. 197 - 204
反应条件
sodium hydroxide; sodium tetrahydroborate; nickel in methanol
参考文献
Hine,J.; Li,W.-S.
Journal of Organic Chemistry, 1975 , vol. 40, # 3 p. 289 - 292
