4-氯吡啶-2,6-二甲酸二乙酯合成路线 （共 11 条）
反应条件
pyridine in dichloromethane T=0 - 20°C; 5 h;
参考文献
Cell Therapeutics, Inc.
Patent: US2004/198728 A1, 2004 ;
Location in patent: Page/Page column 8 ;
反应条件
1: chelidamic acid With trichlorophosphate Heating / reflux; 2: ethanol With triethylamine in tetrahydrofuran T=0 - 20°C; 0.5 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/82487 A2, 2008 ;
Location in patent: Page/Page column 155 ;
WO 2008/082487 A2
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / Heating 2: pyridine View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 21 p. 4703 - 4707
反应条件
1: chelidamic acid With phosphorus pentachloride in chloroform Heating; 2: ethanol
参考文献
Journal of Inorganic Biochemistry, , vol. 112, p. 49 - 58
参考文献
Koenigs; Jaeschke
Chemische Berichte, 1921 , vol. 54, p. 1353
反应条件
Kochen des Reaktionsprodukts mit verd. Salzsaeure und Destillieren;
参考文献
Koenigs; Jaeschke
Chemische Berichte, 1921 , vol. 54, p. 1353
反应条件
copper(l) iodide; palladium diacetate; triphenylphosphine in triethylamine T=80°C; 24 h;
参考文献
Takalo, Harri; Kankare, Jouko
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1987 , vol. 41, # 3 p. 219 - 221
反应条件
1: toluene / Heating
2: HCl / aq. NaOH
3: SOCl2 / ethanol / 7 h / Heating
View Scheme
参考文献
Chavarot, Murielle; Socquet, Stephane; Kotera, Mitsuharu; Lhomme, Jean
Tetrahedron, 1997 , vol. 53, # 40 p. 13749 - 13756
反应条件
in toluene
Heating; Yield given;
参考文献
Chavarot, Murielle; Socquet, Stephane; Kotera, Mitsuharu; Lhomme, Jean
Tetrahedron, 1997 , vol. 53, # 40 p. 13749 - 13756
反应条件
1: 1) NaH, 2) crown ether (18-c-6) / 1) THF, room temp., 1 h, 2) THF, reflux, 1 h
2: 1) KOH, 2) HCl
View Scheme
参考文献
Chaubet; Nguyen Van Duong; Courtieu; Gaudemer; Gref; Crumbliss
Canadian Journal of Chemistry, 1991 , vol. 69, # 7 p. 1107 - 1116
