2,2,2-三氯-1-(4-硝基-1H-吡咯-2-基)-乙酮合成路线 （共 11 条）
反应条件
nitric acid; acetic anhydride T=-40 - 20°C; 12 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 19 p. 3327 - 3342
反应条件
nitric acid in acetic anhydride T=-40 - 20°C; 4 h;
参考文献
Tetrahedron Letters, , vol. 46, # 42 p. 7101 - 7105
反应条件
triethylamine in ethanol T=20°C; 16 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/52852 A1, 2004 ;
Location in patent: Page 31-32 ;
反应条件
1: 88 percent / DMAP / 10 h / 60 °C 2: 80 percent / aq. NaOH / methanol / 20 h / 60 °C View Scheme
参考文献
Kumar, Rohtash; Lown, J. William
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 19 p. 3327 - 3342
反应条件
hydrazine hydrate in ethanol T=20°C; 1 h; Inert atmosphere;
参考文献
Rane, Rajesh A.; Bangalore, Pavankumar; Borhade, Sheetal D.; Khandare, Preeti K.
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 49 - 58
反应条件
1: NaH 2: H2 / 10 percent Pd/C / dimethylformamide / 2 h / 2585.74 Torr View Scheme
参考文献
Bremer, Ryan E.; Szewczyk, Jason W.; Baird, Eldon E.; Dervan, Peter B.
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 1947 - 1955
反应条件
1: T=20°C; 2 h; 2: With sulfuric acid in methanol; water
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; WU, Minwan
Patent: WO2011/150356 A1, 2011 ;
Location in patent: Page/Page column 93 ;
WO 2011/150356 A1
反应条件
in methanol T=20°C; 2 h;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda S.; KOTIAN, Pravin L.; KUMAR, V. Satish; WU, Minwan; LIN, Tsu-Hsing
Patent: WO2011/14817 A1, 2011 ;
Location in patent: Page/Page column 104 ;
WO 2011/014817 A1
反应条件
4-(N,N-dimethlyamino)pyridine T=70°C;
参考文献
Lautru, Sylvie; Song, Lijiang; Demange, Luc; Lombes, Thomas; Galons, Herve; Challis, Gregory L.; Pernodet, Jean-Luc
Angewandte Chemie - International Edition, 2012 , vol. 51, # 30 p. 7454 - 7458
反应条件
1: 88 percent / DMAP / 10 h / 60 °C
2: 80 percent / aq. NaOH / methanol / 20 h / 60 °C
3: 83 percent / H2SO4 / diethyl ether / 36 h / 20 °C
View Scheme
参考文献
Kumar, Rohtash; Lown, J. William
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 19 p. 3327 - 3342
