(S)-(+)-2-甲基溴丁烷合成路线 （共 39 条）
反应条件
Verseifen mit alkoh.KOH und Erhitzen auf 180grad;
参考文献
Levene; Marker
Journal of Biological Chemistry, 1931 , vol. 91, p. 418
Journal of Biological Chemistry, 1932 , vol. 95, p. 3,13
参考文献
Vogler,K.; Chopard-dit-Jean,L.H.
Helvetica Chimica Acta, 1960 , vol. 43, p. 279 - 286
反应条件
1: 78 percent / 1.) Mg / 1.) Et2O, 2.) Et2O, -78 degC, 2 h, then at room temp. overnight
3: CaCO3 / CH2Cl2 / 0.25 h / 150 - 170 °C
View Scheme
参考文献
Martischonok; Melikyan; Mineif; Vostrowsky; Bestmann
Synthesis, 1991 , # 7 p. 560 - 564
反应条件
sodium ethanolate in ethanol
参考文献
Pathak,U.S.; Thakar,K.A.
Journal of the Indian Chemical Society, 1964 , vol. 41, p. 534 - 536
反应条件
1: 4-bromo-1,1'-biphenyl With magnesium in tetrahydrofuran
1 h; Inert atmosphereReflux;
2: (S)-(+)-1-bromo-2-methylbutane With dilithium tetrachlorocuprate in tetrahydrofuran
48 h; RefluxInert atmosphere;
参考文献
Herman, Jakub; Kula, Przemyslaw
Tetrahedron Letters, 2013 , vol. 54, # 28 p. 3621 - 3623
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II); magnesium
1.) ether, 2.) ether, reflux, 5 h; Yield given. Multistep reaction;
参考文献
Kaszynski, P.; Jawdosiuk, M.
Molecular Crystals and Liquid Crystals (1969-1991), 1989 , vol. 174, p. 21 - 38
反应条件
1: NaNH2 / toluene
2: H2S, HCl / ethanol / -78 °C
3: (i) (irradiation), benzene, (ii) Hg(OAc)2, AcOH
View Scheme
参考文献
Couture,A. et al.
Journal of the American Chemical Society, 1976 , vol. 98, p. 6218 - 6225
反应条件
1: NaNH2 / toluene
2: H2S, HCl / ethanol / -78 °C
3: benzene / Irradiation
4: Hg(OAc)2 / acetic acid
View Scheme
参考文献
Couture,A. et al.
Journal of the American Chemical Society, 1976 , vol. 98, p. 6218 - 6225
反应条件
1: NaNH2 / toluene
2: H2S, HCl / ethanol / -78 °C
3: benzene / Irradiation
View Scheme
参考文献
Couture,A. et al.
Journal of the American Chemical Society, 1976 , vol. 98, p. 6218 - 6225
