2,2-二甲基-3-辛酮合成路线 （共 16 条）
反应条件
1-methyl-1H-imidazole; [Cu(MeCN)]4*CF3SO3; 4,4'-dimethoxy-2,2'-bipyridine; ABNO; oxygen in acetonitrile
T=60°C; 1 h;
参考文献
Steves, Janelle E.; Stahl, Shannon S.
Journal of the American Chemical Society, 2013 , vol. 135, # 42 p. 15742 - 15745
反应条件
potassium phosphate; AlO(OH); palladium in toluene
T=110°C; 20 h;
参考文献
Kwon, Min Serk; Kim, Namdu; Seo, Seong Hyeok; Park, In Soo; Cheedrala, Ravi Kumar; Park, Jaiwook
Angewandte Chemie - International Edition, 2005 , vol. 44, # 42 p. 6913 - 6915
反应条件
Grignard reagent; N,N-diphenyl-p-methoxyphenylchloromethyleniminium chloride; copper(l) iodide in tetrahydrofuran; dichloromethane
1) -30 deg C, 1 h, 2) 0 deg C, 1 h;
参考文献
Fujisawa, Tamotsu; Mori, Toshiki; Sato, Toshio
Tetrahedron Letters, 1982 , vol. 23, # 48 p. 5059 - 5062
反应条件
potassium tert-butylate in tetrahydrofuran
T=0°C;
参考文献
Brown,H.C. et al.
Journal of the American Chemical Society, 1969 , vol. 91, p. 2147 - 2149
反应条件
sodium hydroxide; dihydrogen peroxide in tetrahydrofuran
2 h; Ambient temperature;
参考文献
Brown, Herbert C.; Imai, Toshiro; Bhat, N. G.
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5277 - 5282
反应条件
3-methyl-2-amino-pyridine; Wilkinson's catalyst in toluene
T=150°C; 24 h;
参考文献
Jun, Chul-Ho; Lee, Hyuk; Hong, Jun-Bae
Journal of Organic Chemistry, 1997 , vol. 62, # 5 p. 1200 - 1201
反应条件
1: (Z)-(2-acetoxy-3,3-dimethyl-1-butenyl)(phenyl)-λ3-iodane tetrafluoroborate With lithium ethanolate in tetrahydrofuran
T=-78°C;
2: tri-n-butylborane in tetrahydrofuran
T=-78 - 20°C; 1.5 h;
参考文献
Ochiai, Masahito; Tuchimoto, Yoshimi; Higashiura, Nobuyuki
Organic Letters, 2004 , vol. 6, # 9 p. 1505 - 1508
参考文献
Whitmore; Noll; Meunier
Journal of the American Chemical Society, 1939 , vol. 61, p. 683
反应条件
1: 91 percent / diethyl ether; pentane / 1.) -78 deg C, 1 h, 2.) room temp., 2.5 h
2: 54 percent / pyridinium chlorochromate / CH2Cl2 / 11 h
View Scheme
参考文献
Heathcock, , Clayton H.; Lampe, John
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4330 - 4337
反应条件
N-(1-chloro-2-methylprop-1-enyl)-N,N-dimethylamine; copper(l) iodide
1.) THF, dichloromethane, 0 deg C, 3 h; 2.) 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Fujisawa, Tamotsu; Mori, Toshiki; Higuchi, Kazunobu; Sato, Toshio
Chemistry Letters, 1983 , p. 1791 - 1794
