5,6,7,8-四氢喹啉-5-酮合成路线 （共 14 条）
反应条件
ammonium acetate; sodium cyanoborohydride in methanol 48 h; Ambient temperature;
参考文献
Dukat, M.; Fiedler, W.; Dumas, D.; Damaj, I.; Martin, B. R.; et al.
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 11 p. 875 - 888
反应条件
1.1: LDA / tetrahydrofuran / -78 °C 1.2: 57 percent / tetrahydrofuran 2.1: 76 percent / H2 / Raney Ni / methanol 3.1: 62 percent / NaCNBH3; HCl / methanol View Scheme
参考文献
Dickerson, Tobin J.; Lovell, Timothy; Meijler, Michael M.; Noodleman, Louis; Janda, Kim D.
Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6603 - 6609
反应条件
potassium acetate in ethanol; chloroform; water
参考文献
American Cyanamid Company
Patent: US5719278 A1, 1998 ;
US 5719278 A
反应条件
sodium ethanolate in ethanol
T=80°C; Wittig-Horner reaction; 2.5 h;
参考文献
Jacobs, Christoph; Frotscher, Martin; Dannhardt, Gerd; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1841 - 1851
