6-羟基-2H-1,4-苯并嗪-3(4H)-酮合成路线 （共 13 条）
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C;
参考文献
UNIVERSITY OF MASSACHUSETTS
Patent: WO2009/36351 A2, 2009 ;
Location in patent: Page/Page column 21; 22/24 ;
反应条件
sodium hydroxide 3 h;
参考文献
Hashimoto; Ishizaki; Shudo; Okamoto
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3891 - 3896
反应条件
sodium hydride in tetrahydrofuran
T=0 - 20°C; 12 h;
参考文献
UNIVERSITY OF MASSACHUSETTS
Patent: WO2009/36351 A2, 2009 ;
Location in patent: Page/Page column 21; 22/24 ;
反应条件
trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene in chloroform
0.0333333 h; Heating;
参考文献
Itoh, Naoki; Sakamoto, Takeshi; Miyazawa, Etsuko; Kikugawa, Yasuo
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7424 - 7428
反应条件
sodium hydroxide; water in tetrahydrofuran; methanol
1 h; Heating / reflux;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/89915 A1, 2004 ;
Location in patent: Page 142-143 ;
反应条件
trifluoroacetic acid in benzene
24 h; Ambient temperature;
参考文献
Hashimoto; Ishizaki; Shudo; Okamoto
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3891 - 3896
反应条件
1: 64 percent / NaBH4 / 10percent Pd-C / methanol; H2O / 0.25 h
2: 40 percent / 5percent aq. NaCO3 / CH2Cl2 / 0.08 h
3: 45 percent / CF3COOH / benzene / 24 h / Ambient temperature
View Scheme
参考文献
Hashimoto; Ishizaki; Shudo; Okamoto
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3891 - 3896
反应条件
1: 40 percent / 5percent aq. NaCO3 / CH2Cl2 / 0.08 h
2: 45 percent / CF3COOH / benzene / 24 h / Ambient temperature
View Scheme
参考文献
Hashimoto; Ishizaki; Shudo; Okamoto
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3891 - 3896
反应条件
1: 78 percent / acetic acid / 0.5 h / Heating
2: 100 mg / 5percent NaOH / 12 h / Ambient temperature
View Scheme
参考文献
Hashimoto; Ishizaki; Shudo; Okamoto
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3891 - 3896
反应条件
sodium hydroxide in water
参考文献
Coutts,R.T.; Pound,N.J.
Journal of the Chemical Society [Section] C: Organic, 1971 , p. 2696 - 2699
