2-(4-甲氧基苯基)-4,4-二甲基-4,5-二氢-1,3-噁唑合成路线 （共 21 条）
反应条件
1: CH2Cl2 / 2 h / 0 °C 2: SOCl2 View Scheme
参考文献
Heterocycles, , vol. 28, # 1 p. 405 - 410
反应条件
1.1: BuLi / diethyl ether / 4 h / 0 °C 1.2: 84 percent / diethyl ether / 8 h / 20 °C 2.1: 90 percent / 50 percent aq. H2SO4 / ethanol / 20 h / Heating 3.1: 82 percent / hydrazine hydrate; AcOH / 4 h / 80 °C 4.1: 98 percent / POCl3 / acetonitrile / 3 h / Heating 5.1: 80 percent / NaH / dimethylformamide / 20 h / 20 °C 6.1: 99 percent / H2 / PtO2 / tetrahydrofuran / 22 h / 20 °C / 1520 Torr View Scheme
参考文献
Napoletano, Mauro; Norcini, Gabriele; Pellacini, Franco; Marchini, Francesco; Morazzoni, Gabriele; Fattori, Raimondo; Ferlenga, Pierpaolo; Pradella, Lorenzo
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 1 p. 5 - 8
反应条件
1.1: BuLi / diethyl ether / 4 h / 0 °C 1.2: 84 percent / diethyl ether / 8 h / 20 °C 2.1: 90 percent / 50 percent aq. H2SO4 / ethanol / 20 h / Heating 3.1: 82 percent / hydrazine hydrate; AcOH / 4 h / 80 °C 4.1: 98 percent / POCl3 / acetonitrile / 3 h / Heating View Scheme
参考文献
Napoletano, Mauro; Norcini, Gabriele; Pellacini, Franco; Marchini, Francesco; Morazzoni, Gabriele; Fattori, Raimondo; Ferlenga, Pierpaolo; Pradella, Lorenzo
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 1 p. 5 - 8
反应条件
diisobutylaluminium hydride in diethyl ether 3.5 h; Ambient temperature;
参考文献
Meyers, A. I.; Himmelsbach, Richard J.; Reuman, Michael
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4053 - 4058
反应条件
1: 90 percent / DIBAL / diethyl ether / 3.5 h / Ambient temperature 2: 81 percent / H2 / Pd/C / ethanol / 12 h / 2585.7 Torr / Ambient temperature View Scheme
参考文献
Meyers, A. I.; Himmelsbach, Richard J.; Reuman, Michael
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4053 - 4058
反应条件
trichlorophosphate in pyridine T=80°C; 14 h;
参考文献
Dordor, Isabelle M.; Mellor, John M.; Kennewell, Peter D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 6 p. 1253 - 1258
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; α-ethoxy vinyllithium
1.) THF, -78 deg C, 10 h, 2.) THF, -78 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Shimano, Masanao; Meyers
Journal of the American Chemical Society, 1994 , vol. 116, # 23 p. 10815 - 10816
反应条件
n-butyllithium
1.) ether, 0 deg C;
参考文献
Butenschoen, Holger; Winkler, Matthias; Vollhardt, K. Peter C.
Journal of the Chemical Society, Chemical Communications, 1986 , # 5 p. 388 - 390
反应条件
1: 1) n-Butyllithium / 1) THF, ice bath , 6 h, 2) THF, room temperature, 4 h
2: 85 percent / acetonitrile / 12 h / Heating
3: 1) NaBH4, 2) 2N-HCl / 1) ethanol, 0-5 deg C, 2 h, 2) methanol, heating, 30 min
View Scheme
参考文献
Mohan, Raju; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1238 - 1246
反应条件
1: 1) n-Butyllithium / 1) THF, ice bath , 6 h, 2) THF, room temperature, 4 h
2: 85 percent / acetonitrile / 12 h / Heating
3: 1) NaBH4, 2) 2N-HCl / 1) ethanol, 0-5 deg C, 2 h, 2) methanol, heating, 30 min
4: 1) n-Butyllithium / 1) THF, a) -78 deg C, b) room temperature, 1.5 h, 2) THF, a) -78 deg C, 0.5 h, b) room temperature, 16 h
View Scheme
参考文献
Mohan, Raju; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1238 - 1246
