1: in dichloromethane
T=20°C; 1 h;
2: With sodium tris(acetoxy)borohydride in dichloromethane
T=0 - 20°C; 3 h;
3: With hydrogenchloride; sodium hydroxide
Product distribution / selectivity; more than 3 stages;
参考文献
THERAVANCE, INC.
Patent: WO2005/42514 A2, 2005 ;
Location in patent: Page/Page column 30 ;
WO 2005/042514 A2