1-羟乙基-4-氰基-5-氨基吡唑合成路线 (共 4 条)
反应条件
in ethanol T=70°C; 18 h;
参考文献
Baraldi, Pier Giovanni; Cacciari, Barbara; Spalluto, Giampiero; Pineda De Las Infantas Y Villatoro, Maria Jose; Zocchi, Cristina; Dionisotti, Silvio; Ongini, Ennio
Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1164 - 1171
参考文献
Da Settimo, Federico; Primofiore, Giampaolo; La Motta, Concettina; Taliani, Sabrina; Simorini, Francesca; Marini, Anna Maria; Mugnaini, Laura; Lavecchia, Antonio; Novellino, Ettore; Tuscano, Daniela; Martini, Claudia
Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5162 - 5174
反应条件
tetrachloromethane; triphenylphosphine in dichloromethane
T=20°C; 72 h;
参考文献
AMBIT BIOSCIENCES CORPORATION; CHAO, Qi; HADD, Michael, J.; HOLLADAY, Mark, W.; ROWBOTTOM, Martin
Patent: WO2012/30924 A1, 2012 ;
Location in patent: Page/Page column 151 ;
WO 2012/030924 A1
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1956 , vol. 21, p. 1240,1242