5-氨基-4-氰基-3-甲基-1-苯基-1H-吡唑合成路线 （共 10 条）
反应条件
in ethanol 2 h; RefluxAcidic conditions;
参考文献
Allouche, Fatma; Chabchoub, Fahker; Salem, Mansour; Kirsch, Gilbert
Synthetic Communications, 2011 , vol. 41, # 10 p. 1500 - 1507
反应条件
iodine; sodium hydrogencarbonate in tetrahydrofuran; water 15 h; Ambient temperature;
参考文献
Vicentini; Poli; Manfrini; Guarneri; Giori; Brandolini
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 2 p. 133 - 143
反应条件
trichlorophosphate 0.5 h; Heating;
参考文献
Barreiro, Eliezer J.; Camara, Celso A.; Verli, Hugo; Brazil-Mas, Leonora; Castro, Newton G.; Cintra, Wagner M.; Aracava, Yasco; Rodrigues, Carlos R.; Fraga, Carlos A. M.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 7 p. 1144 - 1152
反应条件
1: 84 percent / POCl3 / 7 h / 70 °C 2: 92 percent / NaN3; tetrabutylammonium bromide / dimethylsulfoxide / 24 h / 20 °C 3: 91 percent / Fe; aq. NH4Cl / ethyl acetate / 4 h / 20 °C 4: 92 percent / NH2OH*HCl; pyridine / ethanol / 2 h / 20 °C 5: 65 percent / POCl3 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 7 p. 1144 - 1152
反应条件
1: 92 percent / NaN3; tetrabutylammonium bromide / dimethylsulfoxide / 24 h / 20 °C 2: 91 percent / Fe; aq. NH4Cl / ethyl acetate / 4 h / 20 °C 3: 92 percent / NH2OH*HCl; pyridine / ethanol / 2 h / 20 °C 4: 65 percent / POCl3 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 7 p. 1144 - 1152
反应条件
1: 91 percent / Fe; aq. NH4Cl / ethyl acetate / 4 h / 20 °C 2: 92 percent / NH2OH*HCl; pyridine / ethanol / 2 h / 20 °C 3: 65 percent / POCl3 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 7 p. 1144 - 1152
反应条件
1: 92 percent / NH2OH*HCl; pyridine / ethanol / 2 h / 20 °C 2: 65 percent / POCl3 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 7 p. 1144 - 1152
反应条件
isopentyl nitrite in tetrahydrofuran Heating;
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1607 - 1612
参考文献
Taylor; Hartke
Journal of the American Chemical Society, 1959 , vol. 81, p. 2452,2455
反应条件
1: With sulfuric acid
T=10 - 20°C;
2: With water
Cooling with ice;
3: With potassium carbonate
pH=8 - 9;
参考文献
ZHANG, Xuqing; ABAD, Marta G.; GIBBS, Alan C.; KUO, Gee-Hong; KUO, Lawrence C.; SONG, Fengbin; SUI, Zhihua
Patent: US2011/263559 A1, 2011 ;
Location in patent: Page/Page column 45 ;
US 20110263559 A1
