3-醛基-1H-吲哚-4-甲酸甲酯合成路线 （共 11 条）
反应条件
trichlorophosphate T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
LABORATORIOS DEL DR. ESTEVE, S.A.; DRACONIS PHARMA, S.L.; ALMIRALL, S.A.; TORRENS JOVER, Andoni; MERCÈ VIDAL, Ramon; CALDENTEY FRONTERA, Francesc Xavier; RODRÍGUEZ GARRIDO, Antonio, David; CARCELLER GONZÁLEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/37960 A1, 2013 ;
Location in patent: Page/Page column 82 ;
反应条件
sodium hydroxide; trichlorophosphate in N-methyl-acetamide; diethyl ether; dichloromethane; water
反应条件
sodium acetate; trichlorophosphate in ice-water; water
参考文献
BIOVITRUM AB (publ)
Patent: WO2008/110598 A1, 2008 ;
Location in patent: Page/Page column 30 ;
WO 2008/110598 A1
反应条件
in anhydrous dichloroethane
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US6495541 B1, 2002 ;
反应条件
tert.-butylhydroperoxide; Cl2Ru*(x)H2O; 2-oxo-3,3-dimethyl-butanoic acid in N-methyl-acetamide T=25°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Wu, Wenliang; Su, Weiping
Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 11924 - 11927
反应条件
in N,N-dimethyl-formamide
参考文献
Yamada, Fumio; Somei, Masanori
Heterocycles, 1987 , vol. 26, # 5 p. 1173 - 1176
反应条件
1: 77 percent / soddium chlorite, 2-methylbutene 2: 99 percent / pyridine View Scheme
参考文献
Yamada, Fumio; Somei, Masanori
Heterocycles, 1987 , vol. 26, # 5 p. 1173 - 1176
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
Kali-Chemie Pharma GmbH
Patent: US5272143 A1, 1993 ;
