3-(4-三氟甲基苯基)丙酸合成路线 （共 10 条）
反应条件
10 Pd/C; cyclohexa-1,4-diene in ethyl acetate T=100°C; 0.0833333 h; Microwave irradiation;
参考文献
Quinn, John F.; Razzano, Dana A.; Golden, Kathryn C.; Gregg, Brian T.
Tetrahedron Letters, 2008 , vol. 49, # 42 p. 6137 - 6140
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=4500.45 Torr; 21 h; Product distribution / selectivity;
参考文献
ACTELION PHARMACEUTICALS LTD; ERBECK, Silke; KOBERSTEIN, Ralf; SOI, Antonio; ZISTLER, Andrea
Patent: WO2010/64212 A1, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
1: With potassium carbonate; Pd-Tedicyp catalyst in N,N-dimethyl-formamide T=110°C; Heck reaction; 20 h; 2: With sodium hydroxide; water in N,N-dimethyl-formamide T=50 - 80°C;
参考文献
Lemhadri, Mhamed; Doucet, Henri; Santelli, Maurice
Tetrahedron, 2004 , vol. 60, # 50 p. 11533 - 11540
反应条件
[Rh(OH)(cycloocta-1,5-diene)]2; water T=75°C; Miyaura-Hayashi reaction; 16 h; Inert atmosphere;
参考文献
Vautravers, Nicolas R.; Breit, Bernhard
Synlett, 2011 , # 17 p. 2517 - 2520
反应条件
water in acetonitrile T=120°C; 0.5 h; microwave irradiation;
参考文献
Tetrahedron, , vol. 63, # 2 p. 389 - 395
反应条件
1: 77 percent / triethylammonium formate 2: H2O / acetonitrile / 0.5 h / 120 °C / microwave irradiation View Scheme
参考文献
Tetrahedron, , vol. 63, # 2 p. 389 - 395
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 15.3 h; 2: With methanol in tetrahydrofuran T=0°C;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/78291 A1, 2008 ;
Location in patent: Page/Page column 47 ;
WO 2008/078291 A1
反应条件
chlorosulfonic acid T=0°C; Friedel-Crafts reaction; 1 h;
参考文献
Tetrahedron, , vol. 63, # 2 p. 389 - 395
反应条件
methylphenylsilane; trimethylacetic anhydride; tris(4-methylphenyl)-phosphine; bis(dibenzylideneacetone)-palladium(0) in toluene T=60°C; 20 h; Schlenk techniqueInert atmosphere;
参考文献
Fujihara, Tetsuaki; Cong, Cong; Terao, Jun; Tsuji, Yasushi
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 17 p. 3420 - 3424
反应条件
in toluene
90 h; Reflux; Product distribution / selectivity;
参考文献
ACTELION PHARMACEUTICALS LTD; ERBECK, Silke; KOBERSTEIN, Ralf; SOI, Antonio; ZISTLER, Andrea
Patent: WO2010/64212 A1, 2010 ;
Location in patent: Page/Page column 25 ;
