1-甲基-1H-苯并咪唑-5-羧酸合成路线 （共 6 条）
反应条件
in water T=85°C; 13 h;
参考文献
METHYLGENE, INC.
Patent: WO2005/30704 A1, 2005 ;
Location in patent: Page/Page column 244-245 ;
反应条件
1: With methanol; sodium hydroxide; water T=20°C; 4 h; 2: With formic acid
参考文献
SANWA KAGAKU KENKYUSHO CO., LTD.
Patent: EP1595866 A1, 2005 ;
Location in patent: Page/Page column 26 ;
反应条件
1: With lithium hydroxide; water in 1,4-dioxane T=20°C; 4 h; 2: With hydrogenchloride in water pH=7;
参考文献
WO2006/128670 A1, ;
Page/Page column 123 ;
WO 2006/128670 A1
反应条件
1: water / 14 h / 100 °C 2: hydrogen; palladium on activated charcoal / methanol / 48 h / 20 °C 3: water / 85 °C View Scheme
反应条件
1: hydrogen; palladium on activated charcoal / methanol / 48 h / 20 °C 2: water / 85 °C View Scheme
反应条件
sulfuric acid 7 h; Heating;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 5 p. 991 - 999
