1-(4-甲氧苯基)丙烷-1-OL合成路线 （共 45 条）
反应条件
1: p-toluenesulfonic acid / benzene / Heating
2: 0.17 h / 25 °C / UV-irradiation
View Scheme
参考文献
Roberts, Jeffrey C.; Pincock, James A.
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1480 - 1492
反应条件
toluene-4-sulfonic acid in benzene
Heating; Title compound not separated from byproducts;
参考文献
Roberts, Jeffrey C.; Pincock, James A.
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1480 - 1492
反应条件
1: 4-methoxyphenylpropanol With sodium hydride in tetrahydrofuran; mineral oil
T=0°C; 1 h; Inert atmosphere;
2: methyl iodide in tetrahydrofuran; mineral oil
T=20°C; 8 h; Inert atmosphere;
参考文献
Fan, Xiaohui; Guo, Kun; Guan, Yong-Hong; Fu, Lin-An; Cui, Xiao-Meng; Lv, Hao; Zhu, Hong-Bo
Tetrahedron Letters, 2014 , vol. 55, # 5 p. 1068 - 1071
反应条件
thionyl chloride in dichloromethane
T=-78°C; 0.25 h; Inert atmosphere;
参考文献
Waibel, Michael; Kieser, Karen J.; Carlson, Kathryn E.; Stossi, Fabio; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3560 - 3570
反应条件
thionyl bromide in N-methyl-acetamide; dichloromethane
参考文献
G.D. Searle and Co.
Patent: EP267439 A3, 1988 ;
