反应条件
1.1: N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 15 - 25 °C / Inert atmosphere 2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.5 h / -5 - 20 °C / Inert atmosphere 3.1: methyllithium / tetrahydrofuran; formaldehyde diethyl acetal / 0.75 h / -55 - -40 °C / Inert atmosphere 3.2: 20 °C / 2068.65 - 2585.81 Torr 4.1: caesium carbonate / acetonitrile / 6.5 h / 20 - 75 °C / Inert atmosphere View Scheme
参考文献
Grongsaard, Pintipa; Bulger, Paul G.; Wallace, Debra J.; Tan, Lushi; Chen, Qinghao; Dolman, Sarah J.; Nyrop, Jason; Hoerrner, R. Scott; Weisel, Mark; Arredondo, Juan; Itoh, Takahiro; Xie, Chengfu; Wen, Xianghui; Zhao, Dalian; Muzzio, Daniel J.; Bassan, Ephraim M.; Shultz, C. Scott
Organic Process Research and Development, 2012 , vol. 16, # 5 p. 1069 - 1081