4-(4-氯-苯基)-4-氧代-丁酸乙酯合成路线 （共 18 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 25°C; 18 h;
参考文献
ARES TRADING S.A.; WHITTAKER, Ben; STEELE, Chris; HARDICK, David; MITCHELL, Dale; POMEL, Vincent; QUATTROPANI, Anna; BEHER, Dirk
Patent: WO2014/12614 A1, 2014 ;
Location in patent: Page/Page column 32; 33 ;
反应条件
(PhCO)PdCl(PPh3)2*(CH2Cl2) in chloroform T=90 - 100°C; 24 h;
参考文献
Fujimura, Tsutomu; Aoki, Satoshi; Nakamura, Eiichi
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2809 - 2821
反应条件
potassium cyanide in N,N-dimethyl-formamide T=80°C; 0.25 h;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Okumura, Yoko; Iwamoto, Ken-Ichi; Higashino, Takeo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 6 - 11
反应条件
potassium cyanide in N,N-dimethyl-formamide T=80°C; 0.25 h;
参考文献
Miyashita; Suzuki; Okumura; Higashino
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 252 - 254
反应条件
sulfuric acid T=20°C;
参考文献
Guijarro, David; Pablo, Oscar; Yus, Miguel
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 3647 - 3654
反应条件
Cu(1,1,1,5,5,5-hexafluoroacetylacetonate)2 in o-di-fluorobenzene Heating;
参考文献
Huang, Dan; Yan, Ming; Zhao, Wei-Jie; Shen, Qi
Synthetic Communications, 2005 , vol. 35, # 5 p. 745 - 750
反应条件
in N,N-dimethyl-formamide T=160°C; 6 h;
参考文献
Sangu, Kenichiro; Watanabe, Toru; Takaya, Jun; Iwasawa, Nobuharu
Synlett, 2007 , # 6 p. 929 - 933
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl acetamide; benzene T=60°C; 0.5 h; various co-solvents;
参考文献
Tamaru, Yoshinao; Ochiai, Hirofumi; Nakamura, Tatsuya; Tsubaki, Kazunori; Yoshida, Zen-ichi
Tetrahedron Letters, 1985 , vol. 26, # 45 p. 5559 - 5562
反应条件
1: 66 percent / DBU / dimethylformamide 2: 98 percent / KCN / dimethylformamide / 0.25 h / 80 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 1 p. 6 - 11
反应条件
tris(4-methoxyphenyl)-phosphine in chloroform T=60°C; 24 h; Overall yield = 65 percent;
参考文献
Synthetic Communications, , vol. 43, # 6 p. 848 - 858
