4-(4-氯-苯基)-4-氧代-丁酸乙酯合成路线 （共 18 条）
反应条件
1: 76 percent / diethyl ether; tetrahydrofuran / 1 h / Heating 2: 12 percent / n-Bu4NCN / tetrahydrofuran / 1.5 h / Ambient temperature 3: 66 percent / DBU / dimethylformamide 4: 98 percent / KCN / dimethylformamide / 0.25 h / 80 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 1 p. 6 - 11
反应条件
1: 66 percent / DBU / dimethylformamide 2: 98 percent / KCN / dimethylformamide / 0.25 h / 80 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 1 p. 6 - 11
反应条件
n-butyllithium 1.) ether, 0 deg C, 15 min, 2.) ether, a) -78 deg C, 1 h, b) RT, 1 h; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 14, # 3 p. 291 - 293
反应条件
tetrakis(triphenylphosphine) palladium(0); zinc copper
参考文献
Chemistry Letters, , # 9 p. 881 - 882
反应条件
samarium diiodide; ethanol in tetrahydrofuran 5 h; Heating;
参考文献
Bradley; Williams; Blann; Holzapfel
Synthetic Communications, 2001 , vol. 31, # 2 p. 203 - 209
反应条件
1: Br2, AcOH 2: 48 percent / butan-1-ol / Heating 3: aq. NaOH / ethanol / 1 h / 60 °C 4: SOCl2 / CH2Cl2 / 2 h / Heating 5: CH2Cl2 / Ambient temperature View Scheme
参考文献
Trapani, Giuseppe; Franco, Massimo; Ricciardi, Laura; Latrofa, Andrea; Genchi, Giuseppe; Sanna, Enrico; Tuveri, Francesca; Cagetti, Elisabetta; Biggio, Giovanni; Liso, Gaetano
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3109 - 3118
反应条件
1: With ammonium acetate in methanol T=25°C; 1 h; 2: With sodium cyanoborohydride in methanol 18 h; Reflux;
参考文献
ARES TRADING S.A.; WHITTAKER, Ben; STEELE, Chris; HARDICK, David; MITCHELL, Dale; POMEL, Vincent; QUATTROPANI, Anna; BEHER, Dirk
Patent: WO2014/12614 A1, 2014 ;
Location in patent: Page/Page column 33 ;
反应条件
1: Br2, AcOH 2: 31 percent / butan-1-ol / Heating 3: aq. NaOH / ethanol / 0.5 h / Heating View Scheme
参考文献
Trapani, Giuseppe; Franco, Massimo; Ricciardi, Laura; Latrofa, Andrea; Genchi, Giuseppe; Sanna, Enrico; Tuveri, Francesca; Cagetti, Elisabetta; Biggio, Giovanni; Liso, Gaetano
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3109 - 3118
