(3-氨基-2,6-二氟苯基)-氨基甲酸 1,1-二甲基乙酯合成路线 （共 3 条）
反应条件
palladium on activated charcoal; hydrogen in methanol
15 h;
参考文献
Youai Co., Ltd.; SHIM, Eun Kyong; KIM, Nam Doo; SHIM, Tae Bo; KIM, Seung Yong
Patent: EP2647637 A2, 2013 ;
Location in patent: Paragraph 0057 ;
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
2: sodium azide / CH2Cl2; dimethylformamide / 20 °C
3: CH2Cl2; dimethylformamide / Heating
4: 38 percent / H2 / palladium black / methanol / 20 °C
View Scheme
参考文献
Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
反应条件
1: 87 percent / KNO3; conc. H2SO4 / 20 °C
2: oxalyl chloride; DMF / CH2Cl2 / 20 °C
3: sodium azide / CH2Cl2; dimethylformamide / 20 °C
4: CH2Cl2; dimethylformamide / Heating
5: 38 percent / H2 / palladium black / methanol / 20 °C
View Scheme
参考文献
Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
