4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-4,5-二羟基-6-甲基四氢吡喃-2-基]氧基-12,14-二羟基-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,15,16,17-十四氢环戊烯并[a]菲-17-基]-5H-呋喃-2-酮合成路线 （共 6 条）
5352-63-64-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-4,5-二羟基-6-甲基四氢吡喃-2-基]氧基-12,14-二羟基-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,15,16,17-十四氢环戊烯并[a]菲-17-基]-5H-呋喃-2-酮
→
反应条件
in methanol T=37°C; oxidative cleavage; 0.25 h; Enzymatic reaction; Enzyme kinetics; Further Variations:Reaction partners;
参考文献
Salphati, Laurent; Benet, Leslie Z.
Xenobiotica, 1999 , vol. 29, # 2 p. 171 - 185
→
5352-63-64-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-4,5-二羟基-6-甲基四氢吡喃-2-基]氧基-12,14-二羟基-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,15,16,17-十四氢环戊烯并[a]菲-17-基]-5H-呋喃-2-酮
反应条件
5-aminopentanoic acid in methanol
12 h; Ambient temperature;
参考文献
Adamczyk, Maciej; Grote, Jonathan
Tetrahedron Letters, 1995 , vol. 36, # 1 p. 63 - 66
→
5352-63-64-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-4,5-二羟基-6-甲基四氢吡喃-2-基]氧基-12,14-二羟基-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,15,16,17-十四氢环戊烯并[a]菲-17-基]-5H-呋喃-2-酮
参考文献
Haack et al.
Naturwissenschaften, 1957 , vol. 44, p. 633
→
5352-63-64-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-4,5-二羟基-6-甲基四氢吡喃-2-基]氧基-12,14-二羟基-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,15,16,17-十四氢环戊烯并[a]菲-17-基]-5H-呋喃-2-酮
反应条件
1: 93 percent / ε-aminocaproic acid / methanol / 12 h / Ambient temperature
2: NaIO4
3: 88 percent / δ-aminovaleric acid / methanol / 12 h / Ambient temperature
View Scheme
参考文献
Adamczyk, Maciej; Grote, Jonathan
Tetrahedron Letters, 1995 , vol. 36, # 1 p. 63 - 66
→
5352-63-64-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-4,5-二羟基-6-甲基四氢吡喃-2-基]氧基-12,14-二羟基-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,15,16,17-十四氢环戊烯并[a]菲-17-基]-5H-呋喃-2-酮
反应条件
in methanol
T=37°C; oxidative cleavage; 0.25 h; Enzymatic reaction; Enzyme kinetics; Further Variations:Reaction partners;
参考文献
Salphati, Laurent; Benet, Leslie Z.
Xenobiotica, 1999 , vol. 29, # 2 p. 171 - 185
→
5352-63-64-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-4,5-二羟基-6-甲基四氢吡喃-2-基]氧基-12,14-二羟基-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,15,16,17-十四氢环戊烯并[a]菲-17-基]-5H-呋喃-2-酮+
反应条件
in water
T=37°C; pH = 1.66; in the absence and presence of 1.0E-2 M α-, β- or γ-cyclodextrins; Rate constant;
参考文献
Uekama; Fujinaga; Hirayama; Otagiri; Kurono; Ikeda
The Journal of pharmacy and pharmacology, 1982 , vol. 34, # 10 p. 627 - 630
