4-甲基-2,6-二苯基吡啶合成路线 （共 27 条）
反应条件
Mn(III) 2-pyridinecarboxylate; acetic acid in acetonitrile
T=20°C; 2 h;
参考文献
Wang, Yi-Feng; Toh, Kah Kah; Ng, Eileen Pei Jian; Chiba, Shunsuke
Journal of the American Chemical Society, 2011 , vol. 133, # 16 p. 6411 - 6421
反应条件
tetrafluoroboric acid; hydrogen; nickel in ethanol
P=760 Torr; 16 h; Ambient temperature;
参考文献
Kanemasa Asai; Tanaka
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 375 - 380
反应条件
1: methyl iodide With magnesium in diethyl ether
2: 2,6-diphenyl-4-chloropyridine With NiCl2((PPh3)P)2 in diethyl ether
T=20°C; Kumada-Tamao coupling; Inert atmosphereReflux;
参考文献
Matsumoto, Kouzou; Lnokuchi, Dalsuke; Hirao, Yasukazu; Kurata, Hiroyukl; Sato, Kazunobu; Takul, Takeji; Kubo, Takashl
Organic Letters, 2010 , vol. 12, # 4 p. 836 - 839
反应条件
boron trifluoride diethyl etherate in 1,2-dichloro-ethane
T=70°C; 1 h; Microwave irradiationInert atmosphere;
参考文献
Linder, Igor; Gerhard, Markus; Schefzig, Luise; Andrae, Michal; Bentz, Christoph; Reissig, Hans-Ulrich; Zimmer, Reinhold
European Journal of Organic Chemistry, 2011 , # 30 p. 6070 - 6077
反应条件
in tetrahydrofuran
T=-78°C; 0.75 h;
参考文献
Bates, Robert B.; Gordon, Bernard; Keller, Philip C.; Rund, John V.; Mills, Nancy S.,
Journal of Organic Chemistry, 1980 , vol. 45, # 1 p. 168 - 169
反应条件
1: (d5-cyclopentadienyl)(methylcyclopentadienyl)titanium dichloride With n-butyllithium in tetrahydrofuran
T=0°C;
2: hex-3-yne in tetrahydrofuran
T=-78°C; 1 h;
3: benzonitrile in tetrahydrofuran
1 h; Heating;
参考文献
Xi, Zhenfeng; Sato, Kimihiko; Gao, Ye; Lu, Jianming; Takahashi, Tamotsu
Journal of the American Chemical Society, 2003 , vol. 125, # 32 p. 9568 - 9569
反应条件
1: 68 percent / Et3N / diethyl ether / Ambient temperature
2: 1) (COCl)2, DMSO, 3) Et3N
3: 99 percent / H2, 42percent aq. HBF3 / Raney Ni / ethanol / 16 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Kanemasa Asai; Tanaka
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 375 - 380
反应条件
1: 1) (COCl)2, DMSO, 3) Et3N
2: 99 percent / H2, 42percent aq. HBF3 / Raney Ni / ethanol / 16 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Kanemasa Asai; Tanaka
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 375 - 380
反应条件
1: 68 percent / Et3N / diethyl ether / Ambient temperature
2: 1) (COCl)2, DMSO, 3) Et3N
3: 99 percent / H2, 42percent aq. HBF3 / Raney Ni / ethanol / 16 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Kanemasa Asai; Tanaka
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 375 - 380
反应条件
diethyl ether; phenyllithium
参考文献
Osuch; Levine
Journal of the American Chemical Society, 1956 , vol. 78, p. 1723
