2-氯-3-硝基苯甲酸甲酯合成路线 （共 19 条）
反应条件
1: 2-chloro-3-carboxy-nitrobenzene With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; 6 h;
2: methanol in dichloromethane
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/51533 A2, 2008 ;
Location in patent: Page/Page column 95 ;
WO 2008/051533 A2
反应条件
sulfuric acid in methanol
参考文献
Chugai Seiyaku Kabushiki Kaisha; Sakai, Toshiyuki
Patent: EP2172198 A1, 2010 ;
反应条件
acetic acid in methanol; hexane
参考文献
Sugen. Inc.
Patent: US2003/100555 A1, 2003 ;
US 20030100555 A1
反应条件
oxalyl dichloride; triethylamine; N,N-dimethyl-formamide
T=0°C; 2 h;
参考文献
SCHERING CORPORATION
Patent: WO2009/58728 A1, 2009 ;
Location in patent: Page/Page column 86 ;
WO 2009/058728 A1
反应条件
triethylamine; palladium diacetate in acetonitrile
参考文献
Eli Lilly and Company
Patent: US6177440 B1, 2001 ;
反应条件
sulfuric acid in methanol
参考文献
Hoechst Schering AgrEvo GmbH
Patent: US5658854 A1, 1997 ;
反应条件
in dichloromethane
Product distribution / selectivity;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2006/116412 A2, 2006 ;
Location in patent: Page/Page column 79; 80; 95 ;
WO 2006/116412 A2
反应条件
1: 99 percent
2: H2 / Raney nickel / tetrahydrofuran
3: 86 percent / NaNO2; H(+)
View Scheme
参考文献
Kunz; Schurter; Maetzke
Pesticide Science, 1997 , vol. 50, # 4 p. 275 - 282
反应条件
1.1: acetic acid; zinc; ammonium formate / methanol; tetrahydrofuran / 18 h / 20 °C
2.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C
2.2: 0 - 60 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; TANG, Haifeng; PIO, Barbara; CHOBANIAN, Harry, R.
Patent: WO2013/62900 A1, 2013 ;
