1: 3-thiophenecarbonitrile With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1 h; 2: methyl iodide in tetrahydrofuran T=-78 - 20°C;

1: With hydroxylamine hydrochloride; sodium acetate in ethanol T=70°C; 0.416667 h; 2: With trifluoromethylsulfonic anhydride; triethylamine in dichloromethane T=-70°C;

1: 3-bromo-2-methyl thiophene With magnesium; lithium chloride in tetrahydrofuran Reflux; 2: p-toluenesulphonyl cyanide in tetrahydrofuran T=-5 - 25°C; 2.16667 h; Inert atmosphere;