2-甲基-3-噻吩甲酸甲酯合成路线 （共 10 条）
反应条件
lithium bromide in 1,4-dioxane 20 h; Reflux;
参考文献
Tetrahedron, , vol. 67, # 45 p. 8679 - 8684
反应条件
potassium carbonate in water; acetone; pentane
反应条件
sulfuric acid Reflux;
参考文献
Lang, Martin; Seifert, Markus H.-J.; Wolf, Kristina K.; Aschenbrenner, Andrea; Baumgartner, Roland; Wieber, Tanja; Trentinaglia, Viola; Blisse, Marcus; Tajima, Nobumitsu; Yamashita, Tokuyuki; Vitt, Daniel; Noda, Hitoshi
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5417 - 5422
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Charonnat; Muchowski; Nelson
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 4 p. 1085 - 1087
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C 1.2: -78 - 20 °C 2.1: sulfuric acid / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5417 - 5422
反应条件
N-bromosuccinmide; acetic acid in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5417 - 5422
反应条件
1: N-bromosuccinimide, benzoyl peroxide / CCl4 / 2 h / Heating
2: 68 percent / NaH / dimethylformamide / 1 h / 0 °C
View Scheme
参考文献
Charonnat; Muchowski; Nelson
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 4 p. 1085 - 1087
反应条件
1: N-bromosuccinimide, benzoyl peroxide / CCl4 / 2 h / Heating
2: 68 percent / NaH / dimethylformamide / 1 h / 0 °C
3: 68 percent / LiOH*H2O / methanol; H2O / 0.75 h / 65 °C
View Scheme
参考文献
Charonnat; Muchowski; Nelson
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 4 p. 1085 - 1087
反应条件
1: N-bromosuccinimide, benzoyl peroxide / CCl4 / 2 h / Heating
2: 50 percent / NaH / dimethylformamide / 1 h / 0 °C
View Scheme
参考文献
Charonnat; Muchowski; Nelson
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 4 p. 1085 - 1087
反应条件
1: N-bromosuccinimide, benzoyl peroxide / CCl4 / 2 h / Heating
2: 50 percent / NaH / dimethylformamide / 1 h / 0 °C
3: 82 percent / LiOH*H2O / methanol; H2O / 0.75 h / 65 °C
View Scheme
参考文献
Charonnat; Muchowski; Nelson
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 4 p. 1085 - 1087
