N-(2-氰基乙基)氨基甲酸叔丁酯合成路线 （共 18 条）
反应条件
calcium carbonate in 1,4-dioxane; water T=0 - 20°C;
参考文献
ALMIRALL, S.A.; GRIMA POVEDA, Pedro Manuel; AGUILAR IZQUIERDO, Nuria; MIR CEPEDA, Marta; CARRASCAL RIERA, Marta; TERRICABRAS BELART, Emma; GRACIA FERRER, Jordi; CASALS COLL, Gaspar
Patent: WO2011/35900 A1, 2011 ;
Location in patent: Page/Page column 71 ;
WO 2011/035900 A1
反应条件
triethylamine in ethylene glycol dimethyl ether 4 h; Ambient temperature;
参考文献
Brutsche; Hartke
Archiv der Pharmazie, 1993 , vol. 326, # 5 p. 271 - 276
反应条件
triethylamine in dichloromethane 12 h; Heating;
参考文献
Houssin; Bernier; Henichart
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 681 - 683
反应条件
N-ethyl-N,N-diisopropylamine in ethanol; ethyl acetate
参考文献
US5223516 A1, ;
US 5223516 A
反应条件
tetrabutylammomium bromide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in acetonitrile T=20°C; 0.0833333 h; Inert atmosphereMolecular sieve;
参考文献
Drouet, Fleur; Fontaine, Patrice; Masson, Geraldine; Zhu, Jieping
Synthesis, 2009 , # 8 art. no. T19708SS, p. 1370 - 1374
反应条件
triethylamine; trifluoroacetic anhydride in tetrahydrofuran 1 h; 0 deg C to room temp.,;
参考文献
Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Synthesis, 1988 , # 3 p. 259 - 261
反应条件
1: 1.) Et3N, ethyl carbonochloridate, 2.) 20percent aq. NH3 / 1.) THF, -10 deg C, 20 min., 2.) -10 deg C to room temp., overnight 2: 93 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., View Scheme
参考文献
Synthesis, , # 3 p. 259 - 261
反应条件
1: 88 percent / 1N aq. NaOH / dioxane / 0 deg C to room temp., 2: 1.) Et3N, ethyl carbonochloridate, 2.) 20percent aq. NH3 / 1.) THF, -10 deg C, 20 min., 2.) -10 deg C to room temp., overnight 3: 93 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., View Scheme
参考文献
Synthesis, , # 3 p. 259 - 261
反应条件
1: 4-methyl-morpholine / ethylene glycol dimethyl ether / |Inert atmosphere 2: sodium tetrahydroborate / water / |Inert atmosphere 3: triethylamine / |Inert atmosphere 4: dimethyl sulfoxide / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
反应条件
1: sodium tetrahydroborate / water / |Inert atmosphere 2: triethylamine / |Inert atmosphere 3: dimethyl sulfoxide / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
