N-(2-氰基乙基)氨基甲酸叔丁酯合成路线 （共 18 条）
反应条件
1: triethylamine / |Inert atmosphere 2: dimethyl sulfoxide / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
反应条件
diphenyl phosphoryl azide; triethylamine
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 22, # 8 p. 1795 - 1799
反应条件
in dimethyl sulfoxide Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
反应条件
1: potassium hydroxide / water; ethanol / 90 °C / |Inert atmosphere 2: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 25 °C / |Inert atmosphere View Scheme
参考文献
Xin, Dongyue; Perez, Lisa M.; Ioerger, Thomas R.; Burgess, Kevin
Angewandte Chemie - International Edition, 2014 , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., 2014 , vol. 126, # 14 p. 3668 - 3672,5
反应条件
hydrogen sulfide; diethylamine in N,N-dimethyl-formamide T=55°C; 3.5 h;
参考文献
Barker, Peter L.; Gendler, Paul L.; Rapoport, Henry
Journal of Organic Chemistry, 1981 , vol. 46, # 12 p. 2455 - 2465
反应条件
ammonia; hydrogen; nickel in ethanol T=50°C; P=15514.4 Torr; 8 h;
参考文献
Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Synthesis, 1988 , # 3 p. 259 - 261
反应条件
hydroxylamine in water
参考文献
MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy
Patent: WO2010/100144 A1, 2010 ;
Location in patent: Page/Page column 111 ;
WO 2010/100144 A1
反应条件
1: 85 percent / H2S, diethylamine / dimethylformamide / 3.5 h / 55 °C
2: 89 percent / CH2Cl2 / 12 h / Heating
3: 96 percent / 1.) NH3 / propan-2-ol / 1.) warming, 30 min, 2.) reflux, 12 h
View Scheme
参考文献
Barker, Peter L.; Gendler, Paul L.; Rapoport, Henry
Journal of Organic Chemistry, 1981 , vol. 46, # 12 p. 2455 - 2465
