4-氯-1H-吲哚-2-甲酸乙酯合成路线 （共 10 条）
反应条件
1: in toluene T=20°C; Wittig reaction; 2: With triphenylphosphine; [MoO2Cl2(dmf)2] in toluene 24 h; Heating; Further stages.;
参考文献
Sanz, Roberto; Escribano, Jaime; Pedrosa, Maria R.; Aguado, Rafael; Arnaiz, Francisco J.
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 713 - 718
反应条件
potassium tert-butylate in ethanol; dichloromethane; acetic acid
参考文献
EP1147110 B1, ;
EP 1147110 B1
反应条件
2,6-dimethylpyridine T=120°C; 12 h;
参考文献
Taira, Shin'Ichi; Danjo, Hiroshi; Imamoto, Tsuneo
Tetrahedron Letters, 2002 , vol. 43, # 16 p. 2885 - 2888
反应条件
Bi(NO3)3; PPA in methanol 2 h; Reflux;
参考文献
Sudhakara; Jayadevappa; Mahadevan; Hulikal, Vijaykumar
Synthetic Communications, 2009 , vol. 39, # 14 p. 2506 - 2515
反应条件
1: EtOK / ethanol / Heating 2: aq. HCl 3: FeSO4/NH3 4: H2SO4 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 944 - 948
反应条件
1: 1.) sec-BuLi / 1) THF, -45 deg C, 10 min; 2) THF, -50 deg C, 10 min 2: TFA / CH2Cl2 / 0.33 h View Scheme
参考文献
Synthetic Communications, , vol. 29, # 3 p. 447 - 455
反应条件
1: FeSO4/NH3 2: H2SO4 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 944 - 948
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 944 - 948
参考文献
Helvetica Chimica Acta, , vol. 38, p. 463,465
Gazzetta Chimica Italiana, , vol. 88, p. 1147,1153, 1159
反应条件
1: POCl3; 1,2-dichloro-ethane / Behandeln der Reaktionsloesung mit wss. Natriumacetat 2: aqueous ethanol NaOH; aniline; aqueous HCl / Erhitzen der gebildeten 4-Chlor-3-<phenylimino-methyl>-indol-2-carbonsaeure mit N,N-Dimethyl-anilin auf Siedetemperatur und Erhitzen des erhaltenen Reaktionsgemisches mit Wasser View Scheme
参考文献
Hardegger; Corrodi
Helvetica Chimica Acta, 1955 , vol. 38, p. 468,470
