6-氯-1H-吲哚-2-甲醛合成路线 （共 5 条）
参考文献
Wyeth
Patent: US2003/144282 A1, 2003 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 3.5 h; Inert atmosphere; 2: With manganese(IV) oxide in acetonitrile 18 h;
参考文献
Gore, Vivek; Patel, Pranav; Chang, Chih-Tsung; Sivendran, Sashikala; Kang, Namin; Ouedraogo, Yannick P.; Gravel, Sylvie; Powell, William S.; Rokach, Joshua
Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3725 - 3732
反应条件
1: potassium ethoxide / ethanol; diethyl ether / 22 h / sonication 2: 16.8 g / AcOH; Fe / ethanol / 4 h / Heating 3: LiAlH4 / tetrahydrofuran / 3.5 h / 0 °C 4: 4.23 g / MnO2 / tetrahydrofuran / 16 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 6 p. 1380 - 1400
反应条件
1: 16.8 g / AcOH; Fe / ethanol / 4 h / Heating 2: LiAlH4 / tetrahydrofuran / 3.5 h / 0 °C 3: 4.23 g / MnO2 / tetrahydrofuran / 16 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 6 p. 1380 - 1400
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C 2: manganese(IV) oxide / acetonitrile / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 2 p. 364 - 377
