1-(2',4'-二氟[1,1'-联苯]-4-基)乙烷-1-酮合成路线 （共 8 条）
反应条件
1: 53 percent / conc. hydrochloric acid / ethanol / 3 h / Heating 2: 50 percent / aq. MeOH / 2 h / Heating View Scheme
参考文献
Fisnerova, Ludmila; Brunova, Bohumila; Kocfeldova, Zuzana; Tikalova, Jana; Maturova, Eva; Grimova, Jaroslava
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 11.1 p. 2373 - 2381
反应条件
1: 60 percent / Br2, acetic acid / 2 h / Ambient temperature 2: 1.) NaH / 1.) DMF, 100 deg C, 15 min, 2.) DMF, 100 deg C, 3 h View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 56, # 11.1 p. 2373 - 2381
反应条件
acetic anhydride; aluminium trichloride in dichloromethane; water
参考文献
Merck and Co., Inc.
Patent: US4225730 A1, 1980 ;
反应条件
n-Butyl nitrite in benzene
参考文献
The Boots Company Limited
Patent: US3932499 A1, 1976 ;
反应条件
{[(PhCH2O)2P(CH3)2CHNCH(CH3)2]2PdCl2}; sodium acetate in 1-methyl-pyrrolidin-2-one; water
T=140°C; Suzuki Coupling; 17 h;
参考文献
Guo, Mengping; Wu, Xiaochun; Ge, Junying; Zhu, Zhiyong
Asian Journal of Chemistry, 2013 , vol. 25, # 13 p. 7251 - 7253
反应条件
C40H56Cl2FeN2O4P2; sodium carbonate in water; acetone
T=20°C; Suzuki coupling; 4 h;
参考文献
Guo, Mengping; Zhang, Qiaochu
Tetrahedron Letters, 2009 , vol. 50, # 17 p. 1965 - 1968
反应条件
aluminium trichloride in carbon disulfide
参考文献
Hannah,J. et al.
Journal of Medicinal Chemistry, 1978 , vol. 21, p. 1093 - 1100
反应条件
(i) Mg, Et2O, (ii) /BRN= 2114246/, (iii) TsOH; Multistep reaction;
参考文献
The Boots Comp. LTD.
Patent: FR2231393DE2426160 , 19741974 ;
Chem.Abstr., 1975 , vol. 82, # 125075
