3-氨基-4-羟基苯甲酸甲酯合成路线 （共 42 条）
参考文献
Cavill
Journal of the Society of Chemical Industry, London, 1945 , vol. 64, p. 212,214
反应条件
1: aqueous acetic acid 2: potassium carbonate; acetone / Erhitzen des Reaktionsprodukts mit wss. Schwefelsaeure View Scheme
参考文献
Sabalitschka
Archiv der Pharmazie (Weinheim, Germany), 1934 , vol. 272, p. 383,390
反应条件
N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate in chloroform T=55°C; 16 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2004/7491 A1, 2004 ;
Location in patent: Page 76 ;
反应条件
sodium hydrogencarbonate in ethyl acetate 0.5 h; Ambient temperature;
参考文献
Yamamoto, Takeshi; Hori, Manabu; Watanabe, Ikuo; Tsutsui, Hisayoshi; Harada, Kengo; Ikeda, Shqji; Maruo, Joji; Morita, Tominori; Ohtaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1716 - 1723
反应条件
caesium carbonate in N,N-dimethyl-formamide
参考文献
Geng, Bolin; Comita-Prevoir, Janelle; Eyermann, Charles J.; Reck, Folkert; Fisher, Stewart
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5432 - 5435
反应条件
1: acetic acid / 3.5 h / 60 °C / |Large scale 2: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C / |Large scale 3: nitric acid / nitromethane / 8 h / 20 - 35 °C / |Large scale View Scheme
参考文献
Mao, Yongjun; Liu, Zheng; Yang, Xiaojun; Xia, Xiangfei; Zhang, Rongxia; Li, Jianfeng; Jiang, Xiangrui; Xie, Kai; Zheng, Jin; Zhang, Hui; Suo, Jin; Shen, Jingshan
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 1970 - 1973
反应条件
1: acetic acid / 3.5 h / 60 °C / |Large scale 2: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C / |Large scale 3: nitric acid / nitromethane / 8 h / 20 - 35 °C / |Large scale 4: hydrogen / methanol / 12 h / 20 °C / 760.05 Torr / |Large scale View Scheme
参考文献
Mao, Yongjun; Liu, Zheng; Yang, Xiaojun; Xia, Xiangfei; Zhang, Rongxia; Li, Jianfeng; Jiang, Xiangrui; Xie, Kai; Zheng, Jin; Zhang, Hui; Suo, Jin; Shen, Jingshan
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 1970 - 1973
反应条件
1: acetic acid / 3 h / 60 °C / Large scale reaction 2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C / Large scale reaction View Scheme
参考文献
Mao, Yongjun; Liu, Zheng; Yang, Xiaojun; Xia, Xiangfei; Zhang, Rongxia; Li, Jianfeng; Jiang, Xiangrui; Xie, Kai; Zheng, Jin; Zhang, Hui; Suo, Jin; Shen, Jingshan
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 1970 - 1973
反应条件
1: With potassium carbonate in DMF (N,N-dimethyl-formamide)
T=70°C; 12 h;
2: With hydrogenchloride
T=20°C;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2004/7491 A1, 2004 ;
Location in patent: Page 73 ;
反应条件
1: aq. KOH / ethanol / Heating
2: H2O / 70 - 80 °C
View Scheme
参考文献
Varma; Kapoor
Pharmazie, 1979 , vol. 34, # 7 p. 387 - 389
