2'-溴-4-氯苯乙酮合成路线 （共 272 条）
反应条件
1-amino-2-oxo-4,6-diphenylpyridine DMSO, 1.) 10 h, room temp., 2.) 6 h, 100 deg C; Yield given. Multistep reaction;
参考文献
Alajarin, M.; Fresneda, P. M.; Molina, P.
Synthesis, 1980 , # 10 p. 844 - 845
反应条件
1: acetylacetone With sodium in ethanol T=20°C; 0.5 h; 2: 2-bromo-1-(4-chloro-phenyl)-ethanone in ethanol T=20°C; 0.666667 h;
参考文献
Bijev, Atanas; Yaneva, Diana; Bocheva, Adriana; Stoev, Georgi
Arzneimittel-Forschung/Drug Research, 2006 , vol. 56, # 11 p. 753 - 759
反应条件
1.) EtOH, RT, 1 h, 2.) EtOH, refux, 3 h; Multistep reaction;
参考文献
Sanfilippo; Urbanski; Beers; Eckardt; Falotico; Ginsberg; Offord; Press; Tighe; Tomko; Andrade-Gordon
Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 34 - 41
反应条件
1: 1.) sodium pellets / 1.) toluene, room temp., 3 days, 2.) toluene, 0 deg C, 1 h then room temp., 1 day 2: 49 percent / 12 M hydrochloric acid / ethanol / 24 h / Heating 3: 55 percent / pieces of sodium / ethanol / 24 h / Heating View Scheme
参考文献
Porretta; Scalzo; Chimenti; Bolasco; Biava; Fischetti; Riccardi
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 5 p. 629 - 639
反应条件
1: NaHCO3 / 3 h / 20 °C 2: PhNH2*HBr; DMF / 0.02 h / microwave irradiation View Scheme
参考文献
Synlett, , # 1 art. no. D26805ST, p. 91 - 95
参考文献
Bulletin de la Societe Chimique de France, , vol. <3> 21, p. 66
参考文献
Journal of the Chemical Society, , p. 847,855
反应条件
1.1: 90 percent / K2CO3 / acetone / 48 h / 20 °C 2.1: fuming sulfuric acid / 5 h / 20 °C 2.2: 79 percent / aq. HClO4 3.1: 95 percent / hydrazine hydrate / acetonitrile / 0.33 h / Heating View Scheme
参考文献
Alifanov, Vadim L.; Babaev, Eugene V.
Synthesis, 2007 , # 2 p. 263 - 270
反应条件
sodium hydrogencarbonate in ethanol T=25°C; 6 h;
参考文献
Pal, Manojit; Swamy, Nalivela Kumara; Hameed, P. Shahul; Padakanti, Srinivas; Yeleswarapu, Koteswar Rao
Tetrahedron, 2004 , vol. 60, # 18 p. 3987 - 3997
反应条件
1: 1.) NaH, 2.) NaOMe / 1.) DMF, 70 deg C, 1.5 h, 2.) DMF, 70 deg C, 1.5 h 2: NaBH4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Vinh; Ahmadi; Lopez Delgado; Fernandez Perez; Walters; Smith; Nicholls; Simons
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 2105 - 2108
