2'-溴-4-氯苯乙酮合成路线 （共 272 条）
反应条件
1: 1,4-dioxane; water / 6 h / 20 °C / |Inert atmosphere 2: acetic acid / 5 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Heterocycles, , vol. 89, # 5 p. 1229 - 1236
反应条件
hydrogenchloride; AlCl3 in dichloromethane
参考文献
Millennium Pharmaceuticals, Inc.; Kyowa Hakko Kogyo Co., Ltd.
Patent: US6509346 B2, 2003 ;
反应条件
1: 2-mercapto-4,5-dihydro-thiazole With sodium carbonate in ethanol; water T=20°C; 2: 2-bromo-1-(4-chloro-phenyl)-ethanone in ethanol; water T=20°C;
参考文献
Loghmani-Khouzani, Hossein; Hajiheidari, Dariush
Journal of Fluorine Chemistry, 2010 , vol. 131, # 5 p. 561 - 569
反应条件
bromine in diethyl ether T=0 - 20°C; 2 h; Inert atmosphereDarkness;
参考文献
Nolla-Saltiel, Roberto; Carrillo-Arcos, Ulises Alonso; Porcel, Susana
Synthesis (Germany), 2014 , vol. 46, # 2 p. 165 - 169
反应条件
hydroxylamine hydrochloride in methanol
参考文献
Hartung, Jens; Schwarz, Michaela
Synlett, 1997 , vol. 1997, # 7 p. 848 - 850
参考文献
Collet
Bulletin de la Societe Chimique de France, 1902 , vol. <3> 27, p. 542
反应条件
in ethanol 3 h; Heating;
参考文献
Pattan, Shashikant R.; Sirajunisa, Talath; Pattan, Jayashri
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 2 p. 439 - 441
反应条件
1: NaHCO3 / diethyl ether; ethanol; H2O / 36 h / Ambient temperature 2: Cu / toluene / 0.25 h / Heating 3: 75.5 percent / 10percent aq. NaOH / ethanol / 0.17 h / Heating View Scheme
参考文献
Liu, Wukun; Zhou, Jinpei; Zhang, Huibin; Qian, Hai; Yin, Jiahan; Bensdorf, Kerstin; Gust, Ronald
Letters in Drug Design and Discovery, 2011 , vol. 8, # 10 p. 911 - 917
反应条件
potassium carbonate; potassium hydrogencarbonate in tert-butyl methyl ether
参考文献
R. L. FINE CHEM; RAMESHA, A., R.; ROY, A., K.
Patent: WO2008/139484 A2, 2008 ;
Location in patent: Page/Page column 5,6 ;
反应条件
sodium tetrahydroborate; ethanol T=20 - 40°C;
参考文献
INTERVET INTERNATIONAL B.V.; BRINK, Monika; NIEDERMANN, Hans-Peter; KNELL, Marcus; FENG, Tao; TRZASKA, Scott, T.; COOPER, Arthur, J.; DESAI, Shaileshkumar Ramanlal; GORE, Vinayak Keshav
Patent: WO2012/85645 A1, 2012 ;
Location in patent: Page/Page column 36 ;
