2'-溴-4-氯苯乙酮合成路线 （共 272 条）
反应条件
1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
T=20°C; 0.283333 h; Inert atmosphere;
参考文献
Singh, Santosh; Singh, Pankaj; Rai, Vijai K.; Kapoor, Ritu; Yadav, Lal Dhar S.
Tetrahedron Letters, 2011 , vol. 52, # 1 p. 125 - 128
反应条件
1: ethanol / |Reflux
2: sodium hydroxide; water / ethanol / 20 °C
3: hydrogenchloride / 1,4-dioxane; water / |Reflux
View Scheme
参考文献
Nitta, Aiko; Fujii, Hideaki; Sakami, Satoshi; Satoh, Mikiya; Nakaki, Junko; Satoh, Shiho; Kumagai, Hiroki; Kawai, Hideki
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7036 - 7040
参考文献
Erlenmeyer et al.
Helvetica Chimica Acta, 1950 , vol. 33, p. 1271,1273
反应条件
1: sodium azide; potassium iodide / water; acetonitrile / 1 h / 60 °C / |Green chemistry
2: magnesium sulfate; alcohol dehydrogenase KRED-NADH-110 / isopropyl alcohol; aq. phosphate buffer / 20 h / 30 °C / pH 7 / |Autoclave; |Green chemistry; |Enzymatic reaction
3: hydrogen; sodium hydroxide / water; aq. phosphate buffer / 4 h / 30 °C / 7500.75 Torr / pH 9 / |Green chemistry
View Scheme
参考文献
Schrittwieser, Joerg H.; Coccia, Francesca; Kara, Selin; Grischek, Barbara; Kroutil, Wolfgang; D'Alessandro, Nicola; Hollmann, Frank
Green Chemistry, 2013 , vol. 15, # 12 p. 3318 - 3331
反应条件
1: 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole With sodium hydrogencarbonate in methanol
2: 2-bromo-1-(4-chloro-phenyl)-ethanone in methanol
20 h;
3: With water
T=40°C; 1 h;
参考文献
Radl, Stanislav; Stach, Jan; Cerny, Josef; Klecan, Ondrej
Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 6 p. 1011 - 1022
反应条件
sodium hydrogencarbonate in methanol
T=17 - 24°C; 17 h; Industry scaleExlusion of light;
参考文献
MERCKLE GmbH
Patent: WO2006/100019 A1, 2006 ;
Location in patent: Page/Page column 1; 9; 11-14 ;
反应条件
1: With trimethylsilyl iodide in N,N-dimethyl-formamide
T=0°C; Fridlaender reaction; HeatingSealed;
2: With water in N,N-dimethyl-formamide
T=20°C; Fridlaender reaction; 1 h; Sonication;
参考文献
Ryabukhin, Sergey V.; Naumchik, Vasiliy S.; Plaskon, Andrey S.; Grygorenko, Oleksandr O.; Tolmachev, Andrey A.
Journal of Organic Chemistry, 2011 , vol. 76, # 14 p. 5774 - 5781
反应条件
aluminum oxide
0.0166667 h;
参考文献
Kidwai; Sapra; Bhushan; Misra
Synthetic Communications, 2001 , vol. 31, # 11 p. 1639 - 1645
反应条件
1: triethylamine / ethanol; N,N-dimethyl-formamide / 2 h
2: hydroxylamine hydrochloride; tetrabutylammomium bromide; sodium acetate / 1,4-dioxane; water / 72 h / 20 °C
View Scheme
参考文献
Saravanan; Mohan; Muthusubramanian
Journal of Sulfur Chemistry, 2011 , vol. 32, # 1 p. 71 - 84
反应条件
iodine; zinc in tetrahydrofuran
16 h; Heating;
参考文献
Ceylan, Mustafa; Guerdere, M. Burcu; Budak, Yakup; Kazaz, Cavit; Secen, Hasan
Synthesis, 2004 , # 11 p. 1750 - 1754
