2'-溴-4-氯苯乙酮合成路线 （共 272 条）
反应条件
1: indole-2,3-dione With polymeric BEMP in acetonitrile
T=25°C; deprotonation; 0.166667 h;
2: 2-bromo-1-(4-chloro-phenyl)-ethanone in acetonitrile
T=45°C; Alkylation; 16 h;
参考文献
Shuttleworth, Stephen J.; Nasturica, Daniel; Gervais, Christian; Siddiqui, M. Arshad; Rando, Robert F.; Lee, Nola
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 22 p. 2501 - 2504
反应条件
in ethanol; water
4 h; Heating; Yield given;
参考文献
Nair, M.G.; Boyce, Loretta H.; Berry, Michael A.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3354 - 3357
反应条件
in acetonitrile
T=0°C;
参考文献
Jones, Todd K.; Mani, Neelakandha
Patent: US2005/250948 A1, 2005 ;
Location in patent: Page/Page column 32 ;
参考文献
Beyer,H.; Pommerening,K.
Chemische Berichte, 1966 , vol. 99, p. 2931 - 2936
反应条件
1: diethyl ether
2: aluminium isopropylate; isopropyl alcohol
View Scheme
参考文献
Sadet; Lipszyc; Chenu; et al.
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 277 - 288
反应条件
sodium carbonate in neat (no solvent, solid phase)
T=20°C; Hantzsch Thiazole Synthesis; 0.0833333 h; Green chemistry;
参考文献
Aggarwal, Ranjana; Kumar, Sunil; Singh, Shiv P.
Journal of Sulfur Chemistry, 2012 , vol. 33, # 5 p. 521 - 525,5
反应条件
hydrogenchloride in ethanol
Hantzsch thiazole synthesis; Reflux;
参考文献
Nalajam, Guravaiah; Vedula, Rajeswar Rao
Journal of Chemical Research, 2008 , # 4 p. 195 - 197
反应条件
1: 62 percent / ethanol / 0.75 h / Heating
2: 69 percent / acetic acid / ethanol / 1) reflux, 2) RT
View Scheme
参考文献
Singh, S. P.; Kodali, Dharma R.; Dhindsa, G. S.; Sawhney, S. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 1 p. 30 - 33
反应条件
in ethanol
6 h; Heating;
参考文献
Singh, S. P.; Sehgal, Subhash; Singh, Lukhvinder; Dhawan, S. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 154 - 155
反应条件
1: 81.9 percent / ethanol; H2O
2: 92.6 percent / Heating
3: 72 percent / H2 / Raney-Ni / ethanol / 100 °C / 60004.8 Torr
4: 74.7 percent / 20percent aq. HCl / Heating
View Scheme
参考文献
Maier, Ludwig; Diel, Peter J.
Phosphorus, Sulfur and Silicon and the Related Elements, 1995 , vol. 107, # 1-4 p. 245 - 256
