2'-溴-4-氯苯乙酮合成路线 （共 272 条）
反应条件
1: 48 percent / K2CO3 / acetone / Heating
2: 67 percent / 20percent H2SO4 / Heating
View Scheme
参考文献
Shridhar, D. R.; Sastry, C. V. Reddy; Bansal, O. P.; Rao, P. Pulla
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 3 p. 297 - 299
反应条件
in acetonitrile
T=20°C; 3 h;
参考文献
Schadt, Oliver; Dorsch, Dieter; Schultz, Melanie; Blaukat, Andree
Patent: US2008/318936 A1, 2008 ;
Location in patent: Page/Page column 18 ;
反应条件
in acetonitrile
T=20°C; 3 h;
参考文献
Schadt, Oliver; Dorsch, Dieter; Schultz, Melanie; Blaukat, Andree
Patent: US2008/306052 A1, 2008 ;
Location in patent: Page/Page column 17-18 ;
反应条件
in tetrahydrofuran
T=0 - 20°C; 16 h;
参考文献
Rilatt, Ian; Mirabel, Etienne; Grand, Bruno Le; Perez, Michel
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 903 - 906
反应条件
1: triethylamine / acetone
2: bromine; sodium acetate / acetic acid
View Scheme
参考文献
Chen, Sheng-Qin; Zhang, Yi-Chao; Liu, Fang-Ming
Phosphorus, Sulfur and Silicon and the Related Elements, 2011 , vol. 186, # 2 p. 319 - 325
反应条件
in N,N-dimethyl-formamide
T=20°C; 48 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2006/72353 A1, 2006 ;
Location in patent: Page/Page column 32 ;
反应条件
sodium hydroxide in ethanol
6 h;
参考文献
Singh, Harjit; Aggarwal, Sunil K.; Malhotra, Nageshwar
Tetrahedron, 1984 , vol. 40, # 23 p. 4941 - 4946
反应条件
in N,N-dimethyl-formamide
T=150°C; Hantzsch thiazole synthesis; P=4500.45 Torr; 0.0625 h; Inert atmosphere;
参考文献
Pagano, Nicholas; Heil, Marintha L.; Cosford, Nicholas D. P.
Synthesis (Germany), 2012 , vol. 44, # 16 p. 2537 - 2546
反应条件
in ethanol
3 h; Heating;
参考文献
Kalinowska-Torz, Jadwiga
Acta Poloniae Pharmaceutica, 1994 , vol. 51, # 3 p. 249 - 250
反应条件
1: in toluene
T=0°C; 1.58333 h;
2: With hydrogenchloride in water; toluene
T=0°C; pH=1 - 2; 0.25 h;
参考文献
FOLDRX PHARMACEUTICALS, INC.
Patent: WO2009/62118 A2, 2009 ;
Location in patent: Page/Page column 215-216 ;
