2'-溴-4-氯苯乙酮合成路线 （共 272 条）
反应条件
potassium carbonate in acetone
T=20°C; 48 h;
参考文献
Alifanov, Vadim L.; Babaev, Eugene V.
Synthesis, 2007 , # 2 p. 263 - 270
反应条件
1: K2CO3 / acetone / Heating
2: p-toluenesulfonic acid / benzene / Heating
View Scheme
参考文献
Liu, Guixia; Lu, Xiyan
Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16504 - 16505
反应条件
1: in ethanol
T=20 - 70°C;
2: With sodium hydroxide in ethanol
参考文献
PROXIMAGEN LTD.; NILSSON, Marianne; HARALDSSON, Martin; HENRIKSSON, Sofia; EMOND, Rikard; SAVORY, Edward; SIMPSON, Iain
Patent: WO2010/64020 A1, 2010 ;
Location in patent: Page/Page column 72 ;
反应条件
sodium carbonate in butan-1-ol
2 h; Heating;
参考文献
El-Shafie; Al-Deeb; Hammad; Mustafa; El-Obeid
Scientia Pharmaceutica, 1994 , vol. 62, # 4 p. 389 - 403
反应条件
1: Na2S / ethanol
2: TiCl4; Zn
View Scheme
参考文献
Dang, Yizhe; Chen, Yi
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6901 - 6904
反应条件
hydrogen bromide; dimethyl sulfoxide
T=55°C; 1.5 h;
参考文献
Tanaka; Kawano; Islam; Nishioka; Hatanaka; Ueda
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 5 p. 885 - 891
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide in benzene
T=25°C; 3 h;
参考文献
Yasuda, Makoto; Oh-hata, Tatsuhiro; Shibata, Ikuya; Baba, Akio; Matsuda, Haruo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 7 p. 859 - 866
反应条件
(i), (ii) H2O; Multistep reaction;
参考文献
American Hoechst Corporation
Patent: US3997557 A1, 1976 ;
参考文献
American Hoechst Corporation
Patent: US3931407 A1, 1976 ;
反应条件
1: N,N-dimethyl-formamide / 20 °C
2: water
View Scheme
参考文献
Cranwell, Philippa B.; O'Brien, Matthew; Browne, Duncan L.; Koos, Peter; Polyzos, Anastasios; Pena-Lopez, Miguel; Ley, Steven V.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 30 p. 5774 - 5779
