2'-溴-4-氯苯乙酮合成路线 （共 272 条）
反应条件
sodium carbonate; 1-butylpyridinium tetrafluoroborate
T=20°C; Chichibabin cyclocondensation; 3 h;
参考文献
Xu, Danqian; Liu, Baoyou; Zheng, Mei
Journal of Chemical Research - Part S, 2003 , # 10 p. 645 - 647
反应条件
in N,N-dimethyl-formamide
T=0°C; 2 h;
参考文献
Baji, H.; Flammang, M.; Kimny, T.; Gasquez, F.; Compagnon, P. L.; Delcourt, A.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 7-8 p. 617 - 626
反应条件
triethylamine in acetone
Reflux;
参考文献
Roman, Gheorghe; Vlahakis, Jason Z.; Vukomanovic, Dragic; Nakatsu, Kanji; Szarek, Walter A.
ChemMedChem, 2010 , vol. 5, # 9 p. 1541 - 1555
反应条件
1: acetonitrile / 80 - 85 °C
2: conc. H2SO4, NaNO2 / H2O / 2 h / 0 - 20 °C
View Scheme
参考文献
Krimer, M. Z.; Tashi, B. P.; Roitburd, G. V.; Shtirkov, I. M.; Manaev, S. A.; et al.
Doklady Chemistry, 1989 , vol. 308, # 4-6 p. 299 - 301
Dokl. Akad. Nauk SSSR Ser. Khim., 1989 , vol. 308, # 5 p. 1155 - 1158
反应条件
β-cyclodextrin in water; acetone
T=50°C;
参考文献
Narender; Somi Reddy; Pavan Kumar; Rama Rao
Synthetic Communications, 2005 , vol. 35, # 12 p. 1681 - 1686
反应条件
ethanol; sodium carbonate
参考文献
Judefind; Reid
Journal of the American Chemical Society, 1920 , vol. 42, p. 1049
反应条件
in dimethyl sulfoxide
T=30°C; 0.25 h; Ionic liquid;
参考文献
Dighe, Satish N.; Bhattad, Ravindra V.; Kulkarni, Raghunath R.; Jain, Kishor S.; Srinivasan, Kumar V.
Synthetic Communications, 2010 , vol. 40, # 23 p. 3522 - 3527
反应条件
toluene-4-sulfonic acid in butan-1-ol; benzene
Heating;
参考文献
Heeres, J.; Cutsem, J. Van
Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1360 - 1364
反应条件
toluene-4-sulfonic acid in methanol; ethanol; benzene
参考文献
Janssen Pharmaceutica N.V.
Patent: US3936470 A1, 1976 ;
反应条件
toluene-4-sulfonic acid in butan-1-ol; benzene
Heating;
参考文献
Heeres, J.; Cutsem, J. Van
Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1360 - 1364
