2'-溴-4-氯苯乙酮合成路线 （共 272 条）
反应条件
1: sodium azide; potassium iodide / water; acetonitrile / 1 h / 60 °C / |Green chemistry 2: sodium tetrahydroborate / methanol / 1.25 h / 5 - 20 °C / |Green chemistry 3: hydrogen; magnesium sulfate; sodium hydroxide / water; isopropyl alcohol; aq. phosphate buffer / 4 h / 30 °C / 7500.75 Torr / pH 7 / |Green chemistry View Scheme
参考文献
Schrittwieser, Joerg H.; Coccia, Francesca; Kara, Selin; Grischek, Barbara; Kroutil, Wolfgang; D'Alessandro, Nicola; Hollmann, Frank
Green Chemistry, 2013 , vol. 15, # 12 p. 3318 - 3331
反应条件
water; hydrogen bromide in dimethyl sulfoxide T=80°C; 5 h;
参考文献
MITSUBISHI PHARMA CORPORATION; SANOFI-SYNTHELABO
Patent: WO2004/85408 A1, 2004 ;
Location in patent: Page 276 ;
WO 2004/085408 A1
反应条件
sodium sulfide in methanol T=20 - 60°C; 0.5 h;
参考文献
Drevko, B. I.; Zhukov, O. I.; Kharchenko, V. G.
Russian Journal of Organic Chemistry, 1995 , vol. 31, # 10 p. 1401 - 1404
Zhurnal Organicheskoi Khimii, 1995 , vol. 31, # 10 p. 1548 - 1552
反应条件
1: 75 percent / 2percent NaOH aq / ethanol 2: 55 percent / conc HCl/60percent HClO4 / methanol / Heating View Scheme
参考文献
Singh, Harjit; Aggarwal, Sunil K.; Malhotra, Nageshwar
Tetrahedron, 1984 , vol. 40, # 23 p. 4941 - 4946
参考文献
Liu, Cong; Nie, Yijiao; Yao, Guowei; Dai, Rongji; Deng, Yulin
Journal of Chemical Research, 2014 , vol. 38, # 4 p. 208 - 210
参考文献
Neurogen Corporation; Pfizer Inc.
Patent: US6121260 A1, 2000 ;
US 6121260 A
反应条件
methyltrichloromonosilane; sodium iodide in acetonitrile 2 h; Ambient temperature;
参考文献
Olah, George A.; Husain, Altaf; Singh, Brij P.; Mehrotra, Ashok K.
Journal of Organic Chemistry, 1983 , vol. 48, # 21 p. 3667 - 3672
反应条件
sodium ditelluride; copper dichloride in tetrahydrofuran; N,N-dimethyl-formamide T=-40°C; 2 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 62, # 6 p. 2114 - 2116
反应条件
hydroxymethanesulfinic acid sodium salt in ethanol 1 h; Heating;
参考文献
Synthetic Communications, , vol. 17, # 13 p. 1587 - 1592
反应条件
water T=45°C; P=2100210 Torr; 16 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 36 p. 7321 - 7326
