反应条件
1: 1.) KOt-Bu, 2,2,6,6-tetramethylpiperidine, n-BuLi / 1) THF, hexane, -78 deg C, 20 min; 2) THF, hexane, -50 deg C, 20 min 2: Me2AlCl / CH2Cl2; hexane / 4 h / -78 °C 3: NaOMe, N-chlorosuccinimide / tetrahydrofuran / 15 h / Ambient temperature 4: 85 percent / LiOH, H2O / methanol / 1 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 22 p. 7840 - 7850
