反应条件
1: 1.) butyllithium / 1.) hexane, ether, 0 deg C, 10 min 2.) 2 h 2: 82 percent / N,N-dimethylaminopyridine (DMAP), Et3N / CH2Cl2 / 3 h / Ambient temperature 3: 99 percent / H2, quinoline / Pd (5percent on BaSO4) / 1.5 h 5: 74 percent / H2 / Pd (10percent on C) / methanol / 2 h / 760 Torr 6: 1.) boron trifluoride 2.) aq. sodium hydrogen carbonate / 1.) AcOH, CH2Cl2, 20 deg C, 1.5 h 2.) 15 min 7: 74 percent / Et3N, m-chloroperbenzoic acid / diethyl ether / 20 h / Ambient temperature View Scheme
参考文献
Fleming, Ian; Higgins, Dick; Lawrence, Nicholas J.; Thomas, Andrew P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 24 p. 3331 - 3350
