反应条件
1.1: 100 percent / pyridine; 4-(dimethylamino)pyridine / CH2Cl2 / 1 h / 0 °C
2.1: BuLi / tetrahydrofuran; hexane / 12 h / 0 °C
2.2: 90 percent / 1,2-dibromoethane / tetrahydrofuran; hexane / -78 - 20 °C
3.1: aq. HCl / dioxane / 3 h / Heating
4.1: aq. HCl; NaNO2; KI / 0 °C
4.2: 24.7 g / aq. KI / 2 h / 80 °C
5.1: Zn/Cu; trimethylsilyl chloride; 1,2-dibromoethane / tetrahydrofuran; dimethylformamide / 2 h / Heating
5.2: 90 percent / Pd(PPh3)4 / tetrahydrofuran; dimethylformamide / 12 h / 40 °C
6.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
6.2: 54 percent / ZnCl2; CuCl2 / tetrahydrofuran; hexane / 20 °C
7.1: N,N,N',N'-tetramethylethylenediamine; BuLi / diethyl ether; hexane / 20 °C
7.2: 90 percent / 1,2-dibromo-1,1,2,2-tetrafluoroethane / diethyl ether; hexane; tetrahydrofuran / -78 - 20 °C
8.1: NiCl2(dppe) / diethyl ether / Heating
9.1: BBr3 / CH2Cl2 / 0 °C
View Scheme
参考文献
Ooi, Takashi; Takahashi, Makoto; Yamada, Masao; Tayama, Eiji; Omoto, Kiyoyuki; Maruoka, Keiji
Journal of the American Chemical Society, 2004 , vol. 126, # 4 p. 1150 - 1160
