2-氨基-6-甲氧基苯甲酸合成路线 （共 42 条）
反应条件
1: K2CO3 2: potassium permanganate; water 3: iron (II)-hydroxide; aqueous ammonia View Scheme
参考文献
Journal of the Chemical Society, , p. 1792,1795
反应条件
1: potassium permanganate; water 2: iron (II)-hydroxide; aqueous ammonia View Scheme
参考文献
Journal of the Chemical Society, , p. 1792,1795
反应条件
1: With tert.-butylnitrite; copper dichloride in acetonitrile 18.0833 h; Inert atmosphere; 2: With sodium hydroxide in water pH=~ 14; 3: With hydrogenchloride in water pH=~ 1;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/147165 A1, 2009 ;
Location in patent: Page/Page column 40 ;
WO 2009/147165 A1
反应条件
1: 47percent aq. HBr, NaNO2 2: 47percent aq. HBr, CuBr / CHCl3 / 0.5 h / 40 °C View Scheme
参考文献
Sugaya; Mimura; Kato; Ikuta; Kasai; Tomioka
Synthesis, 1994 , # 1 p. 73 - 76
反应条件
in tetrahydrofuran T=40 - 50°C; 3 h;
参考文献
Darras, Fouad H.; Kling, Beata; Heilmann, Joerg; Decker, Michael
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 11 p. 914 - 919
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: Ac2O / 1 h / Heating 3: AcONH4 / 7 h / 220 °C 4: POCl3 / 3 h / Heating 5: NH2NH2 / tetrahydrofuran / 1 h / 20 °C 6: CHCl3 / 12 h / Heating View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
(i) aq. H2SO4, NaNO2, (ii) KI; Multistep reaction;
参考文献
MERCK SHARP and DOHME CORP.; BUNGARD, Christopher, James; PERKINS, James, J.; MANIKOWSKI, Jesse, J.; DE LEON, Pablo; MEISSNER, Robert, S.
Patent: WO2011/53574 A1, 2011 ;
Location in patent: Page/Page column 27-28 ;
反应条件
1.1: 2 h / Heating 2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C 2.2: tetrahydrofuran / 4.5 h / -78 - 20 °C 2.3: AcOH / tetrahydrofuran / 20 °C View Scheme
参考文献
Boschelli; Wang; Ye; Wu; Zhang; Dutia; Powell; Wissner; Arndt; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 5 p. 822 - 833
反应条件
1.1: 2 h / Heating 2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C 2.2: tetrahydrofuran / 4.5 h / -78 - 20 °C 2.3: AcOH / tetrahydrofuran / 20 °C 3.1: 772 mg / POCl3; DMF / 4 h / Heating View Scheme
参考文献
Boschelli; Wang; Ye; Wu; Zhang; Dutia; Powell; Wissner; Arndt; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 5 p. 822 - 833
反应条件
borane-THF in tetrahydrofuran T=0 - 30°C; 1.66667 h; Inert atmosphere;
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
