1,4-二氮杂双环[3.2.2]-3-壬酮合成路线 （共 8 条）
反应条件
1: With PPA T=120 - 130°C; 2.33333 h; 2: With potassium carbonate in water T=20°C;
参考文献
NEUROSEARCH A/S
Patent: WO2009/62987 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
PPA T=120 - 130°C; 2.33333 h;
参考文献
WO2004/29053 A1, ;
Page 22 ;
WO 2004/029053 A1
反应条件
trifluoroacetic acid T=95°C; 0.166667 h;
参考文献
Costa, Brian R. de; He, Xiao-shu; Linders, Joannes T.M.; Dominguez, Celia; Gu, Zi Qiang; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2311 - 2320
反应条件
sulfuric acid T=180°C; Beckmann rearrangement; 0.25 h; microwave irradiation;
参考文献
Synthetic Communications, , vol. 36, # 3 p. 321 - 326
反应条件
1: hydroxylamine hydrochloride; sodium acetate / water / 1 h / 70 °C 2: polyphosphoric acid / 140 h / 120 - 130 °C View Scheme
参考文献
WO2011/73296 A1, ;
WO 2011/073296 A1
反应条件
sodium hydride 1.) THF, 25 deg C, 1 h, 2.) 2 h.; Yield given. Multistep reaction;
参考文献
Schroeer, Josef; Sanner, Michel; Reymond, Jean-Louis; Lerner, Richard A.
Journal of Organic Chemistry, 1997 , vol. 62, # 10 p. 3220 - 3229
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating;
参考文献
Curtis, Michael P.; Bunnelle, William H.; Pagano, Thomas G.; Gopalakrishnan, Murali; Faghih, Ramin
Synthetic Communications, 2006 , vol. 36, # 3 p. 321 - 326
反应条件
sodium hydroxide in water
T=100°C; 0.5 h;
参考文献
NEUROSEARCH A/S
Patent: WO2005/74940 A1, 2005 ;
Location in patent: Page/Page column 29 ;
WO 2005/074940 A1
